Cholesterol - ≥92.5%(GC), powder,from sheep wool , CAS No.57-88-5

CAS: 57-88-5 Cat. No.: C432976 분자식: C₂₇H₄₆O 분자량: 386.65 Beilstein Registry Number: 1915888 EC 번호: 200-353-2

등급 & 순도 ≥92.5%(GC), powder,from sheep wool

Synonyms

3-beta-Hydroxycholest-5-ene | 3beta-Hydroxycholest-5-ene | Dusoran | epicholesterin | Nimco cholesterol base H | 20-epi-cholesterol | AI3-03112 | 3beta-cholest-5-en-3-ol | 5:6-Cholesten-3-ol | (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylhept

Storage

Room temperature

Shipped In

Normal

개요

Gene Information

human ... POLA1(5422), TOP2A(7153)rat ... Ar(24208), Polb(29240)

Application

Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

사양

동의어

3-beta-Hydroxycholest-5-ene | 3beta-Hydroxycholest-5-ene | Dusoran | epicholesterin | Nimco cholesterol base H | 20-epi-cholesterol | AI3-03112 | 3beta-cholest-5-en-3-ol | 5:6-Cholesten-3-ol | (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylhept

사양 및 순도

≥92.5%(GC), powder,from sheep wool

생화학 및 생리적 메커니즘

Cholesterol is a lipid makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the function

보관 조건

Room temperature

배송

Normal

순수함

≥92.5%(GC)

이름과 식별자

정식 스마일

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

IUPAC Name

(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

InChIKey

HVYWMOMLDIMFJA-DPAQBDIFSA-N

INCHI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

이성체 SMILES

C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

WGK 독일

1

RTECS

FZ8400000

분자량

386.65

Beilstein

1915888

Reaxy-Rn

2060565

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2060565&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • 분류 Steroids and steroid derivatives
      • Subclass Cholestane steroids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• 분류: Steroids and steroid derivatives
• Subclass: Cholestane steroids
• Intermediate Tree Nodes: Not available
• Direct Parent: Cholesterols and derivatives
• Alternative Parents: 3-beta-hydroxysteroids 3-beta-hydroxy delta-5-steroids Delta-5-steroids Secondary alcohols Cyclic alcohols and derivatives Hydrocarbon derivatives
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Cholesterol-skeleton - Cholesterol - 3-beta-hydroxysteroid - 3-beta-hydroxy-delta-5-steroid - Hydroxysteroid - 3-hydroxysteroid - 3-hydroxy-delta-5-steroid - Delta-5-steroid - Cyclic alcohol - Secondary alcohol - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Alcohol - Aliphatic homopolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as cholesterols and derivatives. These are compounds containing a 3-hydroxylated cholestane core.
• External Descriptors: Cholesterol and derivatives

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

CYP46A1 Tchem Cholesterol 24-hydroxylase (2 Activities)

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RORC Tchem Nuclear receptor ROR-gamma (1 Activities)

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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CYP11A1 Tclin Cytochrome P450 11A1 (1 Activities)

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POLA1 Tclin DNA polymerase alpha subunit (225 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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NPC1L1 Tclin Niemann-Pick C1-like protein 1 (346 Activities)

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POLB Tchem DNA polymerase beta (23632 Activities)

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NR1H3 Tchem LXR-alpha (2891 Activities)

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CCRF-CEM (65223 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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MCF7 (126967 Activities)

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SH-SY5Y (11521 Activities)

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SW480 (6023 Activities)

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U-937 (7138 Activities)

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A549 (127892 Activities)

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BJ (6930 Activities)

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T47D (39041 Activities)

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NCI-H69 (709 Activities)

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HCT-116 (91556 Activities)

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KB (17409 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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SMMC-7721 (5516 Activities)

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ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)

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SNCA Tchem Alpha-synuclein (10960 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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SULT2B1 Tbio Sulfotransferase family cytosolic 2B member 1 (4 Activities)

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

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CYP46A1 Tchem Cholesterol 24-hydroxylase (289 Activities)

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관련 대상(비인간)

ERG11 Cytochrome P450 51 (617 Activities)

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Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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Abcb1b P-glycoprotein 1 (174 Activities)

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Top2 DNA topoisomerase II (15 Activities)

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Salmonella typhimurium (15756 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Streptococcus pyogenes (16140 Activities)

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Bacillus sp. (164 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Cutibacterium acnes (887 Activities)

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Rattus norvegicus (775804 Activities)

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P19 (309 Activities)

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Vero (26788 Activities)

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C2C12 (756 Activities)

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cyp125 Putative cytochrome P450 125 (56 Activities)

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env Envelope glycoprotein (1 Activities)

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Phytophthora cactorum (113 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Brucella pseudogrignonensis (43 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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Scn2a Sodium channel alpha subunits; brain (Types I, II, III) (344 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: water: soluble 0.00003g/L at20°C
• 특정 회전[α]: -37 ° (C=2, Dioxane)
• 끓는점(°C): 360°C
• 녹는점(°C): 148.5°C
• 분자량: 386.700 g/mol
• XLogP3: 8.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 386.355 Da
• Monoisotopic Mass: 386.355 Da
• Topological Polar Surface Area: 20.200 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 591.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 8
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1