CK869 - ≥98% , CAS No.388592-44-7

CAS: 388592-44-7 Cat. No.: C275421 분자식: C₁₇H₁₆BrNO₃S 분자량: 394.28 EC 번호: 686-022-7

GRADE & PURITY ≥98%

Synonyms

HMS623C22 | CCG-33400 | 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone | D80737 | BS-17180 | EX-A2784 | SR-01000553731-1 | CK 869 | CK 869; CK869; CK-0157869; CK 0157869; CK0157869 | 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Product description

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

Product Application

CK-869 has been used as an Arp2/3 complex inhibitor:

to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly

to induce membrane blebbing in HT1080 fibrosarcoma cells

to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Specifications

동의어

HMS623C22 | CCG-33400 | 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone | D80737 | BS-17180 | EX-A2784 | SR-01000553731-1 | CK 869 | CK 869; CK869; CK-0157869; CK 0157869; CK0157869 | 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC 50 = 11 μM) and inhibits the formation of actin filament comet tails by Listeria monocytogenes in infected SKOV3 cells (

보관 조건

Protected from light,Store at -20°C

배송

Ice chest + Ice pads

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참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥98%

이름과 식별자

• Pubchem Sid: 488194457
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488194457
• 정식 스마일: COC1=CC(=C(C=C1)N2C(SCC2=O)C3=CC(=CC=C3)Br)OC
• IUPAC Name: 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one
• InChIKey: MVWNPZYLNLATCH-UHFFFAOYSA-N
• INCHI: 1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
• 이성체 SMILES: COC1=CC(=C(C=C1)N2C(SCC2=O)C3=CC(=CC=C3)Br)OC
• WGK 독일: 3
• 분자량: 394.28
• Reaxy-Rn: 19720233
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19720233&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Methoxybenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Methoxybenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Dimethoxybenzenes
• Alternative Parents: Methoxyanilines Phenoxy compounds Anisoles Alkyl aryl ethers Bromobenzenes Aryl bromides Thiazolidines Tertiary carboxylic acid amides Lactams Dialkylthioethers Azacyclic compounds Carbonyl compounds Organonitrogen compounds Organic oxides Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: M-dimethoxybenzene - Dimethoxybenzene - Methoxyaniline - Phenoxy compound - Anisole - Phenol ether - Alkyl aryl ether - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Tertiary carboxylic acid amide - Thiazolidine - Carboxamide group - Lactam - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Azacycle - Dialkylthioether - Thioether - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as dimethoxybenzenes. These are organic aromatic compounds containing a monocyclic benzene moiety carrying exactly two methoxy groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in DMSO to 100 mM
• 감도: light sensitive
• 분자량: 394.300 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 393.003 Da
• Monoisotopic Mass: 393.003 Da
• Topological Polar Surface Area: 64.099 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 425.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1