CLK-IN-T3 - 10mM in DMSO , CAS No.2109805-56-1

CAS: 2109805-56-1 Cat. No.: C655185 분자식: C₂₈H₃₀N₆O₂ 분자량: 482.58

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC 50 s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity

In Vitro

CLK-IN-T3 inhibits DYRK1A (IC 50 =260 nM) and DYRK1B (IC 50 =230 nM). CLK-IN-T3 (0.1-10.0 µM; 24 hours) results in mild cell cycle arrest at the G2/M boundary with long-duration (24 h). CLK-IN-T3 (0.5-1.0 µM; 6 hours) decreases phosphorylation of CLK-targeted SR proteins and CLK proteins increase slightly. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle AnalysisCell Line: HCT-116 cells Concentration: 0.1, 0.5, 1.0, 5.0, 10.0 µM Incubation Time: 24 hours Result: Resulted in mild cell cycle arrest at the G2/M boundary with long-duration (24 h). Western Blot AnalysisCell Line: HCT-116 cells Concentration: 0.5, 1.0 μM Incubation Time: 6 hours Result: Decreased phosphorylation of CLK-targeted SR proteins and CLK proteins increased slightly.

IC50& Target:CLK1 0.67 nM (IC 50 ) CLK2 15 nM (IC 50 ) CLK3 110 nM (IC 50 ) DYRK1A 260 nM (IC 50 ) DYRK1B 230 nM (IC 50 )

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC 50 s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

• 이성체 SMILES: CC(C)(C1=CC=C(C=C1)C(=O)NC2=CN3C=C(C=CC3=N2)C4=CC=NC=C4)C(=O)N5CCN(CC5)C
• 분자량: 482.58

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2109805-56-1, the molecular formula is C28H30N6O2, and the molecular weight is 482.58 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.