DTT Solution - 1M in H2O , CAS No.3483-12-3

CAS: 3483-12-3 Cat. No.: D301909 분자식: C₄H₁₀O₂S₂ 분자량: 154.25 Beilstein Registry Number: 1719760 EC 번호: 222-468-7

등급 & 순도 1M in H2O

Synonyms

DTT | AKOS005259570 | Threitol, 1,4-dithio-, L- | (+/-)-1,4-Dimercapto-2,3-butanediol | 2-propylpenten-2-oic Acid | AKOS015855399 | MFCD00004877 | dithio threitol | AC-37037 | DL-Dithiothreitol, >=99.0% (RT) | 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Product introduction

DTT is similar to mercaptoethanol, and it is a reducing agent and deprotection agent for sulfhydryl DNA. 1M DTT solution (in water) is often used as a basic component to reduce disulfide bonds in protein, which has antioxidant effect. The pungent odor and toxicity of DTT are much lower than those of mercaptoethanol.

Usage

1 according to the specific requirements of the experiment.

Scope of use

Applicable to general biology and medical research

Product use

Dithiothreitol is an effective reducing agent for protein analysis. When preparing samples for electrophoresis or other applications, sealed ampoules are more convenient and easy to use, and waste and loss of efficacy can be avoided.

사양

동의어

DTT | AKOS005259570 | Threitol, 1,4-dithio-, L- | (+/-)-1,4-Dimercapto-2,3-butanediol | 2-propylpenten-2-oic Acid | AKOS015855399 | MFCD00004877 | dithio threitol | AC-37037 | DL-Dithiothreitol, >=99.0% (RT) | 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-

사양 및 순도

1M in H2O

생화학 및 생리적 메커니즘

Cell-permeable reducing reagent. Prevents oxidation of thiol groups. Protective and protein purification agent. Active in vivo and in vitro .

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

이름과 식별자

Pubchem Sid

528764245

정식 스마일

O[C@H](CS)[C@H](O)CS

IUPAC Name

(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol

InChIKey

VHJLVAABSRFDPM-QWWZWVQMSA-N

INCHI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1

이성체 SMILES

C([C@H]([C@@H](CS)O)O)S

WGK 독일

3

RTECS

EK1610000

대체 CAS

27565-41-9

분자량

154.25

Beilstein

1719760

Reaxy-Rn

9483598

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9483598&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • 분류 Organooxygen compounds
      • Subclass Alcohols and polyols
        • Level5 Polyols
          • Level6 1,2-diols

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• 분류: Organooxygen compounds
• Subclass: Alcohols and polyols
• Intermediate Tree Nodes: Polyols
• Direct Parent: 1,2-diols
• Alternative Parents: Secondary alcohols Alkylthiols Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Secondary alcohol - 1,2-diol - Alkylthiol - Hydrocarbon derivative - Organosulfur compound - Aliphatic acyclic compound
• 설명: This compound belongs to the class of organic compounds known as 1,2-diols. These are polyols containing an alcohol group at two adjacent positions.
• External Descriptors: 1,4-dithiothreitol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(비인간)

Trypanosoma brucei brucei (13300 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pgaB Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase (23 Activities)

Discover Target: pgaB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: H2O: soluble 50 mg/mL, clear, colorless to very faintly yellow
• 감도: Air & Heat and Moisture Sensitive
• 발화점(°F): 235.4 °F
• 발화점(°C): 113 °C
• 끓는점(°C): 125～130°C
• 녹는점(°C): 42-43°C
• 분자량: 154.300 g/mol
• XLogP3: -0.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 154.012 Da
• Monoisotopic Mass: 154.012 Da
• Topological Polar Surface Area: 42.500 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 52.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1