1-(4-Fluorophenethyl)piperazine: Properties & Lab FAQ

1-(4-Fluorophenethyl)piperazine is a fluorinated piperazine derivative widely used as a building block and reference standard in medicinal chemistry and pharmacological research.

Chemical Name

1-(4-Fluorophenethyl)piperazine

SKU / Product Code

P725775

Compound Class

Arylpiperazine (fluorinated secondary amine)

Core Structural Features

Piperazine ring N-substituted with a 4-fluorophenethyl chain

Primary Application

Medicinal chemistry building block; pharmacological probe synthesis

Supplier

Aladdin Scientific

Overview and Chemical Identity

1-(4-Fluorophenethyl)piperazine (SKU: P725775) is a member of the arylpiperazine family, characterised by a piperazine ring bearing a 4-fluorophenethyl substituent on one nitrogen atom. The para-fluorine substituent confers useful metabolic stability and lipophilicity tuning properties that make this scaffold attractive in drug-discovery programmes. The compound contains one secondary amine (the unsubstituted piperazine nitrogen) available for further functionalisation, enabling rapid library synthesis of more complex pharmacological agents.

Its molecular framework is frequently encountered in the design of central-nervous-system (CNS)-active compounds, receptor ligands, and synthetic intermediates, although researchers should consult primary literature for specific biological activity data relevant to their application.

Solubility, Storage, and Handling

Solubility: Arylpiperazine derivatives of this type are generally soluble in common organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and dichloromethane. Aqueous solubility may be limited at neutral pH but can improve under acidic conditions due to protonation of the piperazine nitrogens. Always prepare a fresh stock solution and verify concentration by an appropriate analytical method.

Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area away from light, heat, and incompatible materials (strong oxidisers, strong acids). Specific storage temperature recommendations should be confirmed from the product certificate of analysis (CoA) supplied with each batch.

Handling: Use appropriate personal protective equipment (PPE) including gloves, laboratory coat, and eye protection. Handle in a fume hood where possible. Refer to the product Safety Data Sheet (SDS) for full hazard information before use.

Applications in Research

1-(4-Fluorophenethyl)piperazine serves primarily as a versatile synthetic building block in medicinal chemistry. Key research applications include:

• Building block synthesis: The free NH of the piperazine nitrogen enables acylation, sulfonylation, reductive amination, and alkylation reactions to generate structurally diverse analogues for structure–activity relationship (SAR) studies.
• Reference standard: May be used as an analytical reference compound in method development, including HPLC and mass spectrometry workflows.
• Pharmacological probes: The 4-fluorophenethylpiperazine motif appears in compounds studied for receptor-binding activity; researchers should validate specific target engagement with appropriate assays.

All end-use applications remain the responsibility of the researcher, and Aladdin Scientific reagents are supplied for research purposes only.

Ordering and Quality Information

1-(4-Fluorophenethyl)piperazine is available from Aladdin Scientific under SKU P725775. When placing an order, researchers and procurement teams should note the following:

• Confirm the required pack size and purity grade prior to ordering; contact Aladdin Scientific technical support if custom quantities or higher purity grades are required.
• A Certificate of Analysis (CoA) is available for each production batch and can be requested at the time of order or downloaded from the Aladdin Scientific website using the batch/lot number.
• An up-to-date Safety Data Sheet (SDS) is available upon request and must be reviewed before handling the compound.
• For pricing, availability, and lead times, please visit the Aladdin Scientific website or contact your regional sales representative.

Frequently asked questions

What is 1-(4-Fluorophenethyl)piperazine used for in research?

It is primarily used as a synthetic building block in medicinal chemistry, enabling the preparation of structurally diverse piperazine analogues for structure–activity relationship (SAR) studies. It may also serve as an analytical reference standard in chromatographic or mass spectrometric method development.

What solvents can I use to dissolve 1-(4-Fluorophenethyl)piperazine?

Arylpiperazine compounds of this type are generally soluble in polar organic solvents such as DMSO, ethanol, and dichloromethane. Aqueous solubility is typically limited at neutral pH but may increase under acidic conditions. It is recommended to verify solubility empirically and confirm stock solution concentration before use.

How should I store 1-(4-Fluorophenethyl)piperazine to maintain its stability?

Store the compound in a tightly sealed container in a cool, dry, and well-ventilated location, away from direct light, heat sources, strong oxidisers, and strong acids. Always consult the batch-specific Certificate of Analysis (CoA) and the Safety Data Sheet (SDS) for confirmed storage temperature and stability data.

What safety precautions should I take when handling this compound?

Always wear appropriate PPE including chemically resistant gloves, a laboratory coat, and safety eyewear. Handle the compound in a fume hood to minimise inhalation exposure. Review the full Safety Data Sheet (SDS) for hazard classifications, first-aid measures, and disposal requirements before working with the material.

How do I obtain a Certificate of Analysis (CoA) or Safety Data Sheet (SDS) for P725775?

The CoA for each batch of P725775 can be downloaded from the Aladdin Scientific website by entering the batch or lot number, or requested at the time of purchase. The SDS is available upon request from Aladdin Scientific customer service or can be accessed through the product page on the website.

References

1. Aladdin Scientific product listing: 1-(4-Fluorophenethyl)piperazine, SKU P725775. Aladdin Scientific (internal source material).
2. General physicochemical and handling properties of piperazine derivatives — textbook-level knowledge; specific data for this compound should be confirmed via CoA and SDS.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.