5-(4-Bromophenyl)pyrrolidin-2-one: FAQs & Key Facts

5-(4-Bromophenyl)pyrrolidin-2-one is a brominated gamma-lactam building block widely used as a synthetic intermediate in medicinal chemistry and heterocyclic compound research.

CAS Number

Not specified in source material — see product page for confirmed CAS

Molecular Formula

C10H10BrNO

Molecular Weight

240.10 g/mol (calculated)

Compound Class

Gamma-lactam (pyrrolidin-2-one) bearing a 4-bromophenyl substituent

Key Functional Groups

Lactam carbonyl, aryl bromide, secondary amine (NH)

Primary Application

Synthetic intermediate in pharmaceutical and heterocyclic chemistry research

SKU

B191993

Product Overview and Chemical Identity

5-(4-Bromophenyl)pyrrolidin-2-one (SKU: B191993) is a five-membered cyclic lactam featuring a 4-bromophenyl group at the 5-position of the pyrrolidin-2-one ring. The compound possesses three synthetically valuable functional handles: the lactam carbonyl, the aryl bromide, and the NH group. This combination makes it a versatile building block for constructing more complex molecular architectures via cross-coupling, N-alkylation, or ring-opening strategies. The presence of the aryl bromide is particularly attractive for palladium-catalyzed reactions such as Suzuki–Miyaura and Buchwald–Hartwig couplings, enabling rapid diversification of the scaffold. Aladdin Scientific supplies this compound as catalog item B191993 for use in research and development settings.

Handling, Storage, and Safety

As with all fine chemical reagents, standard laboratory precautions should be observed when working with 5-(4-Bromophenyl)pyrrolidin-2-one. Personnel should wear appropriate personal protective equipment including gloves, safety glasses, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of dust or aerosols. The compound should be stored in a cool, dry location away from incompatible materials such as strong oxidizers and strong bases. The container should be kept tightly sealed when not in use to prevent moisture ingress, which can affect purity and stability over time. Specific hazard classifications and first-aid measures are detailed in the Safety Data Sheet (SDS) available on the Aladdin Scientific product page for B191993; researchers should consult the SDS before first use.

Note: Specific GHS classifications and hazard pictograms for this compound are not listed in the available source material. Verify current SDS data on the product page.

Purity, Grade, and Quality Specifications

Aladdin Scientific offers 5-(4-Bromophenyl)pyrrolidin-2-one (B191993) as a research-grade reagent. Typical quality attributes expected for this class of compound include identity confirmation by NMR spectroscopy or mass spectrometry and purity assessment by HPLC or GC analysis. Researchers requiring lot-specific certificates of analysis (CoA) with confirmed purity values, melting point data, and analytical trace data should request these documents at the time of ordering or download them directly from the product page using the lot number printed on the container label. If your application demands a higher purity specification, contact Aladdin Scientific technical support to discuss availability of custom grades or alternative purification options.

Note: Exact purity percentage figures and analytical methods for catalog item B191993 are not stated in the provided source material and should be verified against the current CoA.

Research Applications and Synthetic Utility

The gamma-lactam (pyrrolidin-2-one) ring system is a privileged scaffold found in numerous bioactive natural products and pharmaceutical agents, contributing to metabolic stability and favorable pharmacokinetic properties. 5-(4-Bromophenyl)pyrrolidin-2-one is particularly well-suited as a starting material or intermediate for medicinal chemistry programs targeting CNS disorders, pain, or anti-infective agents, where pyrrolidinone motifs frequently appear. The aryl bromide at the para position of the phenyl ring offers a convenient handle for:

• Palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Sonogashira, Buchwald–Hartwig)
• Lithium–halogen exchange for organolithium generation
• Copper-mediated Ullmann-type reactions

The NH group allows N-functionalization via alkylation or acylation, providing further structural diversity. These combined attributes make B191993 a useful reagent in the construction of compound libraries for high-throughput screening.

Ordering, Shipping, and Returns

5-(4-Bromophenyl)pyrrolidin-2-one (B191993) can be ordered directly through the Aladdin Scientific website. When placing an order, please have your institution purchase order number, shipping address, and any required project codes ready. Standard packaging complies with relevant regulations for transport of research chemicals. For questions about available pack sizes, bulk pricing, or lead times, contact Aladdin Scientific customer service or your regional sales representative.

Regarding returns: if the product arrives damaged, is incorrect, or does not meet the specifications stated on the CoA, please contact Aladdin Scientific customer service within the applicable return window (see current Returns and Refunds policy on the website) and retain all original packaging and documentation. Perishable or custom-synthesized items may be subject to different return conditions. For shipping and delivery queries — including tracking, international customs, and cold-chain requirements — refer to the Shipping and Delivery section of the Aladdin Scientific help center or contact customer support directly.

Frequently asked questions

What is 5-(4-Bromophenyl)pyrrolidin-2-one used for in research?

5-(4-Bromophenyl)pyrrolidin-2-one is used primarily as a synthetic building block and intermediate in medicinal chemistry and heterocyclic compound synthesis. Its aryl bromide group is amenable to palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald–Hartwig), while the lactam NH enables N-functionalization, allowing chemists to rapidly generate structurally diverse analogs for biological screening.

How should I store 5-(4-Bromophenyl)pyrrolidin-2-one to maintain its purity?

Store 5-(4-Bromophenyl)pyrrolidin-2-one in a tightly sealed container in a cool, dry location away from moisture, light, and incompatible materials such as strong oxidizers or strong bases. Always consult the Safety Data Sheet (SDS) and Certificate of Analysis (CoA) available on the Aladdin Scientific product page for B191993 for specific storage temperature recommendations and shelf-life information.

Where can I find the Certificate of Analysis (CoA) for catalog item B191993?

The Certificate of Analysis for B191993 can be downloaded directly from the Aladdin Scientific product page. Enter the lot number printed on your container label in the CoA search tool to retrieve the batch-specific document containing purity data, analytical results, and other quality information. If you cannot locate your CoA online, contact Aladdin Scientific customer service for assistance.

Can 5-(4-Bromophenyl)pyrrolidin-2-one undergo palladium-catalyzed cross-coupling reactions?

Yes. The aryl bromide functionality at the para position of the phenyl ring makes 5-(4-Bromophenyl)pyrrolidin-2-one a suitable substrate for a range of palladium-catalyzed cross-coupling reactions, including Suzuki–Miyaura (with boronic acids), Negishi, Sonogashira, and Buchwald–Hartwig amination reactions. Researchers should optimize reaction conditions including catalyst loading, ligand choice, base, and solvent for their specific transformation.

What should I do if my order of B191993 arrives damaged or is incorrect?

If your order arrives damaged or is incorrect, contact Aladdin Scientific customer service as soon as possible within the return window specified in the current Returns and Refunds policy. Retain all original packaging, labels, and documentation, as these will be required to process your claim. Your customer service representative will guide you through the replacement or refund procedure.

References

1. Aladdin Scientific product page for 5-(4-Bromophenyl)pyrrolidin-2-one, SKU B191993.
2. General reference: March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 7th ed. Smith, M. B. Wiley, 2013. (For cross-coupling reaction types described.)
3. General reference: Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry, 2nd ed. Oxford University Press, 2012. (Lactam chemistry and heterocycle synthesis.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.