Proteins Involved in Apoptosis

Apoptosis is a regulated process of programmed cell death in which cells initiate internal signaling pathways that lead to their own elimination. This mechanism is essential for normal development and tissue homeostasis, but it can also be triggered by external stressors such as hypoxia, ionic disturbances, or infection.

Disruption of apoptosis contributes to a wide range of diseases, including tissue atrophy, neurodegenerative disorders, autoimmune conditions, and cancer. In many cancers, apoptotic pathways are suppressed, enabling cells to survive beyond their natural lifespan. This prolonged survival allows the accumulation and propagation of damaged or misfolded proteins during continued cell division.

Key proteins controlling apoptosis are frequently mutated or dysregulated in cancerous cells. Notable examples include the tumor suppressor p53 and anti-apoptotic regulators such as Bcl-2 and XIAP. p53 functions by halting the cell cycle at the G1 checkpoint following DNA damage, promoting either DNA repair or the initiation of apoptosis. Negative regulators like MDM2 and related proteins inhibit p53 activity, while blocking these regulators restores p53 function.

Members of the Bcl family (e.g., Bcl-2, Bcl-xL) act as apoptosis inhibitors by preventing the release of cytochrome C and suppressing caspase activation, both of which are central events in apoptotic signaling. Similarly, inhibitor of apoptosis proteins (IAPs) such as XIAP and survivin promote cell survival by directly binding caspases and blocking their activation.

Aladdin carries a wide variety of Proteins Involved in Apoptosis, including both Bcl and IAP Inhibitors and Apoptosis Activators, see details in the below sheet.

Bcl Inhibitors

Product ID	Pouduct name	Purity	Description
G107461  G107460  G421065	Gossypol Acetic Acid	≥97% analytical standard ≥98% 10mM in DMSO	Bcl-2, Bcl-xl, sialyl transferase inhibitor.
A124869  V408685	ABT-199	≥99% 10mM in DMSO	BH3 mimetic; Bcl-2 inhibitor.
A276560  N408031	ABT-263 (Navitoclax)	≥98%  10mM in DMSO	BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.
A127419  A408945	ABT-737	≥97% 10mM in DMSO	BH3 mimetic; Bcl-2, Bxl-xl, Bcl-w inhibitor.
O420059  O580471	Obatoclax	≥98% 10mM in DMSO	BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

IAP Inhibitors

Product ID	Pouduct name	Purity	Description
L127178 L420283	LCL-161	≥99% 10mM in DMSO	SMAC mimetic; PXR agonist, IAP inhibitor.
B129259  B421093	TL-32711	≥98% 10mM in DMSO	Smac mimetic; IAP inhibitor.
Y126171 Y408082	YM-155	≥98% 10mM in DMSO	Survivin inhibitor.

Other Apoptosis Activators

Product ID	Pouduct name	Purity	Description
D275187	DMAPT	≥98%	Water-soluble parthenolide analog; NF-κB inhibitor.
S126246  S408324	JNJ-26854165	≥98% 10mM in DMSO	MDM2 inhibitor.
N129848	NSC-207895	≥98%	Benzofuroxan derivative; MDMX inhibitor
N126055	Nutlin-3	≥98%	Imidzoline derivative; MDM2 inhibitor.
R125421  R408483	RITA	≥98% 10mM in DMSO	p53 activator.

Aladdin: https://www.aladdinsci.com/