RNA interference-based knockdown technology in animals
RNAi is a type of gene silencing that occurs through in vivo shearing to form small (~21 nt) double-stranded RNAs in which the antisense strand is complementary
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Preparation of transgenic animals by somatic cell nuclear transfer technique
Nuclear transplantation is a technical process in which the nucleus of an embryonic cell or adult cell is transferred into a denucleated oocyte using microsurgi
Animal model of tibial metaphyseal osteotomy lengthening
Inequality of limb length, especially in the lower limbs, is a common orthopedic clinical disorder that seriously affects patients' life, work and study. The ma
Animal model of cartilage defects in the knee joint
Since the knee joint is the largest joint in the body, its range of motion is large, the soft tissue coverage is extensive, and the synovial tissue is also the
Animal models of rheumatoid arthritis
Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic polyarticular inflammation, the etiology and pathogenesis of which are not fully
Animal model of ischemic necrosis of the femoral head
Currently, the clinical causes of femoral head necrosis can be divided into two categories: traumatic and non-traumatic. Traumatic necrosis of the femoral head
Animal models of the skeletal system
Fractures and bone defects are the focus and difficulty of treatment in orthopaedics, and their repair process is affected by a variety of factors, while the lo
Animal model of infected bone defects
Bone infections can lead to osteomyelitis, a bone disease that is second only to cancer in terms of difficulty in management and high recurrence rate. Osteomyel
Stochastic Mutagenesis based on Chemical ENUs
ENU is an alkylating agent that delivers ethyl to oxygen or nitrogen groups on DNA, resulting in base mismatches or substitutions (primarily inducing point muta