ADAR1 is an important RNA-editing enzyme that catalyzes adenosine-to-inosine (A-to-I) editing in double-stranded RNA (dsRNA), reducing the recognition of endogenous dsRNA by nucleic acid-sensing systems such as MDA5, PKR, and ZBP1. Tumor cells can exploit ADAR1 to maintain RNA immune tolerance, ...
Topic
MDA5
Techniques for detecting, quantifying and localizing antigens and antibodies — ELISA, Western blotting, immunohistochemistry and flow cytometry. Below are the protocols, FAQs and technical articles in our knowledge base tagged with this topic.
2 resources · protocols, FAQs & articles
Interferon-stimulated genes (ISGs) constitute the core effector layer for establishing the cellular antiviral state. After viral RNA is recognized by pattern recognition receptors such as RIG-I and MDA5, type I/type III interferon production can be induced through MAVS, TBK1, IRF3/IRF7, and ...
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Techniques often explored alongside immunological experiments.