FFN511 - ≥98% , CAS No.1004548-96-2

CAS: 1004548-96-2 Cat. No.: F274714 분자식: C₁₇H₂0N₂O₂ 분자량: 284.35

GRADE & PURITY ≥98%

Synonyms

9-(2-aminoethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

개요

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices。

Specifications

동의어

9-(2-aminoethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity. Inhibits 5-HT binding to VMAT2 (IC 50 = 1 µM (comparable to dopamine itself)). Released via exocytosis in the striatum in mouse acute slice preparati

보관 조건

Store at -20°C,Desiccated

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. To make a 10 μM solution for slice incubation, 25 μl of a 20 mM FFN511 stock solution in DMSO is added to 50 ml of ACSF. This results in a 10 μM FFN511 solution in ACSF containing 0.05% DMSO. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥98%

이름과 식별자

• Pubchem Sid: 528764452
• 정식 스마일: C1CC2=CC3=C(C4=C2N(C1)CCC4)OC(=O)C=C3CCN.C(=O)(C(F)(F)F)O
• IUPAC Name: 6-(2-aminoethyl)-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2(7),5,8-tetraen-4-one;2,2,2-trifluoroacetic acid
• InChIKey: XHUSAIWAUAMZRG-UHFFFAOYSA-N
• INCHI: 1S/C17H20N2O2.C2HF3O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17;3-2(4,5)1(6)7/h9-10H,1-8,18H2;(H,6,7)
• 이성체 SMILES: C1CC2=CC3=C(C4=C2N(C1)CCC4)OC(=O)C=C3CCN.C(=O)(C(F)(F)F)O
• 분자량: 284.35
• Reaxy-Rn: 23051490
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23051490&ln=

화학 및 물리적 특성

• 용해성: Soluble in DMSO to 100 mM and in ethanol to 100 mM

참고 문헌

1. Chen Zhou, Feifei Wu, Liqing He, Huijie Yan, Zhaowei Zhang, Shuang Zhao, Wenyi Huang, Yuhao Luo, Wei Zhao, Bulong Gao, Zherui Zhang, Yaofeng Zhou, Baiheng Wu, Junqiu Liu, Dingcheng Zhu.  (2025)  An Implant-Free Nanosystem Enabling Synergistic Oxidative Damage Mitigation and Deep Brain Stimulation for Alleviating Parkinsonian Symptoms.  ACS Nano,      [PMID:40664603] [10.1021/acsnano.5c06227]