LGD-6972 - Moligand™, 10mM in DMSO , CAS No.1207989-09-0

CAS: 1207989-09-0 Cat. No.: L655135 분자식: C₄₃H₄₆N₂O₅S 분자량: 702.90 PubChem CID: 44625560

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

In Vitro

In vitro, LGD-6972 binds competitively to Glukagon receptor (GCGR) with high affinity and selectivity, suppressing both cAMP and glucose production. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, LGD-6972 reduces acute Glukagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting Glukagon receptor signaling . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

이름과 식별자

• 이성체 SMILES: CC1=CC(=C(C(=C1)C)C2=CC=C(C=C2)NC(=O)[C@H](CC3=CC=C(C=C3)C(=O)NCCS(=O)(=O)O)C4=CC=C(C=C4)C5=CC=C(C=C5)C(C)(C)C)C
• 대체 CAS: 1207989-09-0
• PubChem CID: 44625560
• MeSH 용어: 2-((4-((2R)-2-(4-(4-tert-butylphenyl)phenyl)-3-oxo-3-(4-(2,4,6-trimethylphenyl)anilino)propyl)benzoyl)amino)ethanesulfonic acid;LGD-6972;RVT-1502
• 분자량: 702.90