≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
Licochalcone B is an extract from the root of Glycyrrhiza uralensis . Licochalcone B inhibits amyloid β ( 42 ) self-aggregation ( IC 50 =2.16 μM) and disaggregate pre-formed Aβ 42 fibrils, reduce metal-induced Aβ 42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction
In Vitro
Licochalcone B (IC 50 : 2.16 μM) inhibits self-mediated Aβ42 aggregation and disaggregates Aβ42 pre-formed fibrils. Licochalcone B (0-12 μM, 48 h) reduces the ROS generation and protects cells from H 2 O 2 -induced cell death in SH-SY5Y cells. Licochalcone B (10 μM, 1 h) inhibits LPS-induced NF-κB activation in RAW264.7 cells. Licochalcone B (10 μM, 1 h) inhibits the LPS-induced phosphorylation of NF-κB p65 at serine 276, and inhibited the expression of TNFα and MCP-1. Licochalcone B (0-20 μM, 24 or 48 h) inhibits human NSCLC cell growth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 cells Concentration: 10 µM Incubation Time: 1 h Result: Inhibited the phosphorylation of NF-κB at serine 276 but not at serine 536.
In Vivo
Licochalcone B (1-25 mg/kg, oral gavage) alleviates oxidative stress of hepatotoxicity in mice induced by CCl 4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice induced by CCl 4Dosage: 1, 5, 25 mg/kg Administration: Oral gavage. Result: Elevated the levels of SOD and GSH, and reduced the GSSG levels.
Licochalcone B is an extract from the root of Glycyrrhiza uralensis . Licochalcone B inhibits amyloid β ( 42 ) self-aggregation ( IC 50 =2.16 μM) and disaggregate pre-formed Aβ 42 fibrils, reduce metal-induced Aβ 42 aggregation through chelating metal io
This compound belongs to the class of organic compounds known as retrochalcones. These are a form of normal chalcones that are structurally distinguished by the lack of oxygen functionalities at the C2'- and C6'-positions.
External Descriptors
Chalcones and dihydrochalcones
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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What is the purity of this product?
This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 58749-23-8, the molecular formula is C16H14O5, and the molecular weight is 286.28 g/mol. InChIKey DRDRYGIIYOPBBZ-XBXARRHUSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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