LMD-009 - 10mM in DMSO , CAS No.950195-51-4

CAS: 950195-51-4 Cat. No.: L656840 분자식: C₂₉H₃₃N₃O₃ 분자량: 471.59 PubChem CID: 91032188

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC 50 s from 11 to 87 nM

In Vitro

LMD-009 (0-20 nM; 90 min) stimulates inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor. LMD-009 (0-100 nM; 1 h) mediates calcium release in Chinese hamster ovary cells. LMD-009 (0.1 nM-100 μM; 40 min) induces L1.2 cells migration. LMD-009 (0-10 μM; 90 min) exhibits different molecular interaction with CCR8 mutations in COS-7 cells. LMD-009 (0-10 nM; 90 min) exhibits no antagonist activity to other human chemokine receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: COS-7 cells Concentration: 0-20 nM Incubation Time: 90 min Result: Stimulated inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor with an EC 50 value of 11 nM. Inhibited none of the receptors of other human chemokine receptors. Cell Viability AssayCell Line: Chinese hamster ovary cells Concentration: 0-100 nM Incubation Time: 1 hour Result: Regulated calcium release in Chinese hamster ovary cells with an EC 50 value 87 nM. Cell Migration AssayCell Line: Lymphocyte L1.2 cells. Concentration: 0.1 nM- 100 μM Incubation Time: 40 min Result: Exhibited an K i value of 66 nM with L1.2 cells and specifically bound 125 I-CCL1.

IC50& Target:CCR8 11-87 nM (EC 50 )

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC 50 s from 11 to 87 nM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

AGONIST

이름과 식별자

• 이성체 SMILES: COC1=CC=CC=C1OC2=CC=CC(=C2)CN3CCC4(CC3)C(=O)NCN4CCC5=CC=CC=C5
• PubChem CID: 91032188
• 분자량: 471.59

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 950195-51-4, the molecular formula is C29H33N3O3, and the molecular weight is 471.59 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.