Lornoxicam - ≥98%(HPLC) , CAS No.70374-39-9

CAS: 70374-39-9 Cat. No.: L129341 분자식: C₁₃H₁₀ClN₃O₄S₂ 분자량: 371.82 EC 번호: 630-354-7

GRADE & PURITY ≥98%(HPLC)

Synonyms

Ro 13-9297 | FT-0630797 | HY-14469 | Lorcam (TN) | LORNOXICAM [INN] | Taigalor | D01866 | Lornoxicam (JAN/USAN/INN) | Telos | AKOS021982478 | BDBM92331 | CHEBI:31783 | CLTX | LORNOXICAM [JAN] | Lornoxicamum | NCGC00346667-02 | 6-Chloro-4-hydroxy-2-methyl-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.
A cyclooxygenase inhibitor.

Specifications

동의어

Ro 13-9297 | FT-0630797 | HY-14469 | Lorcam (TN) | LORNOXICAM [INN] | Taigalor | D01866 | Lornoxicam (JAN/USAN/INN) | Telos | AKOS021982478 | BDBM92331 | CHEBI:31783 | CLTX | LORNOXICAM [JAN] | Lornoxicamum | NCGC00346667-02 | 6-Chloro-4-hydroxy-2-methyl-

사양 및 순도

≥98%(HPLC)

생화학 및 생리적 메커니즘

Lornoxicam is a cyclooxygenase inhibitor. Structurally similar to Tenoxicam. An anti-inflammatory and an analgesic. Lornoxicam is an inhibitor of Cox-1 and Cox-2.Potent COX-1 and COX-2 inhibitor (IC 50 = 5 and 8 nM for COX-1 and COX-2, respectively). Inhi

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

ACTIVATOR

참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥98%(HPLC)

이름과 식별자

Pubchem Sid

504771374

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504771374

정식 스마일

CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3

IUPAC Name

6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide

InChIKey

WLHQHAUOOXYABV-UHFFFAOYSA-N

INCHI

1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)

이성체 SMILES

CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3

WGK 독일

3

RTECS

XJ9095000

분자량

371.82

Reaxy-Rn

1039965

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1039965&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 분류 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 분류: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Alpha amino acids and derivatives
• Alternative Parents: Thienothiazines 2,3,5-trisubstituted thiophenes N-arylamides 1,2-thiazines Aryl chlorides Imidolactams Organosulfonamides Pyridines and derivatives Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-amino acid or derivatives - Thienothiazine - N-arylamide - 2,3,5-trisubstituted thiophene - Ortho-thiazine - Aryl chloride - Aryl halide - Organosulfonic acid amide - Pyridine - Imidolactam - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Vinylogous acid - Thiophene - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
• External Descriptors: monocarboxylic acid amide - organochlorine compound - pyridines - heteroaryl hydroxy compound - thienothiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: Soluble in water (<1 mg/ml at 25 °C), methanol (sparingly), DMSO (2 mg/ml at 25 °C), DMF, and ethanol (<1 mg/ml).
• 감도: Heat sensitive
• 녹는점(°C): 230°C
• 분자량: 371.800 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 370.98 Da
• Monoisotopic Mass: 370.98 Da
• Topological Polar Surface Area: 136.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 634.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 70374-39-9, the molecular formula is C13H10ClN3O4S2, and the molecular weight is 371.82 g/mol. InChIKey WLHQHAUOOXYABV-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.