Velzatinib(M4205) - Moligand™,≥99% , CAS No.2590556-80-0

CAS: 2590556-80-0 Cat. No.: M650715 분자식: C₂₉H₃₂N₈O 분자량: 508.62 PubChem CID: 155587867

등급 & 순도 Moligand™, ≥99%

Synonyms

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

M4205 is a c-KIT inhibitor, with an IC 50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

Form:Solid

IC50& Target:c-KIT

사양

동의어

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

사양 및 순도

Moligand™,≥99%

생화학 및 생리적 메커니즘

Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

정식 스마일

CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6

IUPAC Name

N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine

InChIKey

LVMAULGVWBINFP-UHFFFAOYSA-N

INCHI

1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)

이성체 SMILES

CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6

대체 CAS

2590556-80-0

PubChem CID

155587867

분자량

508.62

화학 및 물리적 특성

• 용해성: DMSO : 11.11 mg/mL (21.84 mM; ultrasonic and warming and heat to 66°C)
• 분자량: 508.600 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 508.27 Da
• Monoisotopic Mass: 508.27 Da
• Topological Polar Surface Area: 85.400 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 715.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2590556-80-0, the molecular formula is C29H32N8O, and the molecular weight is 508.62 g/mol. InChIKey LVMAULGVWBINFP-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.