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M4K2234 - ≥98% , CAS No.2421141-51-5
주문 가능
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC 50 s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer
In Vitro
M4K2234 (0-5 μM) shows inhibitory effects against WT and DIPG-linked mutant forms of ALK2 with IC 50 s of 5, 3, 6 and 6 nM for WT, G328V, R206H and R258G, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
1.19 Pharmacokinetic Properties of M4K2234 in Mice . Mice PO 3 mg/kg C max (ng/mL) 1650 AUC inf (ng·h/mL) 4630 t 1/2 (h) 2.61 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 5 nM (ALK2 WT), 3 nM (ALK2 G328V), 6 nM (ALK2 R206H), 6 nM (ALK2 R258G), 2144 nM (ALK5)
Specifications
사양 및 순도
≥98%
생화학 및 생리적 메커니즘
M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC 50 s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer.
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
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작업 유형
INHIBITOR
순수함
≥98%
이름과 식별자
| 분자량 | 462.56 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
화학 및 물리적 특성
| 용해성 | DMSO : 100 mg/mL (216.19 mM; Need ultrasonic) |
|---|
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