Mitoxantrone - Moligand™, 10 mM in DMSO , CAS No.65271-80-9

CAS: 65271-80-9 Cat. No.: M1496363 분자식: C₂₂H₂₈N₄O₆ 분자량: 444.48 Beilstein Registry Number: 2795126 EC 번호: 833-758-3

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

Specifications

사양 및 순도

Moligand™, 10 mM in DMSO

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

제품 특성

• pKa: pKa: 7.08 (Predicted), pKa: 9.27 (Predicted)
• Ki 데이터: mAChR M2: Ki= 77.9 nM (human); mAChR M4: Ki= 89.8 nM (human); mAChR M1: Ki= 0.18 μM (human); SR-2C: Ki= 1.87 μM (human); HERG: Ki= 2.94 μM (human)

이름과 식별자

• 이성체 SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
• RTECS: CB5748500
• 분자량: 444.48
• Beilstein: 2795126
• Reaxy-Rn: 2795126
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2795126&ln=

화학 및 물리적 특성

• 굴절률: n20D1.71
• 끓는점(°C): ~805.7° C at 760 mmHg (Predicted)
• 녹는점(°C): 170-174° C

참고 문헌

1. Zhi Li, Shuhua Han.  (2022)  A Chemosensor of 1,8-Dihydroxyanthraquinone PMOs Prepared in a Ternary Deep Eutectic Solvent for the Sensitive Detection of Cu2+.  ACS Omega,      [PMID:35811913] [10.1021/acsomega.2c01944]

2. Chunli Lou, Xiongzhen Ye, Ge Chen, Jidong Zhu, Jingwu Kang.  (2020)  Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:33340746] [10.1016/j.chroma.2020.461790]

3. Tao Xiaojun, Tao Ting, Wen Yi, Yi Jiajin, He Lihua, Huang Zixuan, Nie Yu, Yao Xiaoyan, Wang Yingying, He Chunlian, Yang Xiaoping.  (2018)  Novel Delivery of Mitoxantrone with Hydrophobically Modified Pullulan Nanoparticles to Inhibit Bladder Cancer Cell and the Effect of Nano-drug Size on Inhibition Efficiency.  Nanoscale Research Letters,  13  (1): (1-12).  [PMID:30377872] [10.1186/s11671-018-2769-x]

4. Qianyu Xu, Haoyang Fu, Jiyuan Gu, Liyu Lei, Lan Ling.  (2024)  Catalytic detoxification of mitoxantrone by graphitic carbon nitride (g-C3N4) supported Fe/Pd bimetallic nanoparticles.  Journal of Environmental Sciences,      [PMID:39095194] [10.1016/j.jes.2024.01.044]

5. Tao Yanru, Zhao Hua, Xiang Yujie, Li Jin, Li Yanting, Hu Jiangling, Wang Hongmei, Jiang Xinhui.  (2024)  Development and Validation of a New High-Performance Liquid Chromatography-Ultraviolet Assay for Quantification of Mitoxantrone in Plasma of BALB/c-nu Mice.  JOURNAL OF CHROMATOGRAPHIC SCIENCE,      [PMID:38493310] [10.1093/chromsci/bmae007]

6. Yixuan Zhao, Jiahui Zhao, Shuqin Liu, Dunqing Wang, Jian Liu, Fei Zhang, Xiangshu Chen.  (2024)  Melamine enhancing Cu-Fenton reaction for degradation of anthracyclines.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39362119] [10.1016/j.jhazmat.2024.136035]

7. Haiying Liu, Yuqi Liu, Xiaoxi Lin, Jianhui Fan, Zhao Huang, Ao Li.  (2024)  Mitoxantrone attenuates lipopolysaccharide-induced acute lung injury via inhibition of NEDD8 activating enzyme.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:39541844] [10.1016/j.intimp.2024.113605]

8. Hongjie Zhang, Rui Geng, Benyan Zheng, Jing Wang, Yuan Hu, Xiaopeng Ma.  (2025)  Ultrasound-Enhanced Mitochondrial Targeting for Synergistic Mitoxantrone-Based Nanotherapy in Triple-Negative Breast Cancer.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.4c06594]

9. Chang Liu, Zhilin Hao, Ziming Wang, Kun Cui, Chen Zhang, Jingrong Wang, Lulu Guo, Fuqiang Liu, Qixin Deng, Zi Yang, Xudong Chen, Maojun Yang, Jianping Xie, Sensen Zhang, Jian Mao.  (2026)  Structure of the Insect Alkaline Taste Receptor Alka and Insights into Its Alkaline Ligand Recognition Mechanism.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:41601143] [10.1021/acs.jafc.5c13948]

10. Peipei Xu, Junpeng Su, Junhua Zhan, Junbo Huang, Junjie Ren, Yu Chen, Lu Chen, Hanhao Lu, Jingbo Chen, Zhenhua Liu, Jing Zhuang, Yudong Lu.  (2026)  Ultrasensitive and separation-free SERS detection of mitoxantrone in plasma via a charge-selective composite hydrogel.  TALANTA,      [PMID:42556042] [10.1016/j.talanta.2026.130389]

11. Bohan Zhang, Jinying Lin, Wenzheng Wu, Zhenglong Chen, Ruiyun You, Yudong Lu, Tao Zhang, Yong Fan.  (2026)  A hydrogel-based SERS sensor: Detecting anthracycline anticancer drugs in plasma without pretreatment and enabling intelligent identification.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.180253]

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 65271-80-9, the molecular formula is C22H28N4O6, and the molecular weight is 444.48 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.