MMPIP - 몰리건드™, ≥98% , Allosteric modulator of mGlu 7 receptor, CAS No.479077-02-6, Allosteric modulator of mGlu 7 receptor

CAS: 479077-02-6 Cat. No.: M274723 분자식: C₁₉H₁₆ClN₃O₃ 분자량: 333.34 EC 번호: 663-556-9

GRADE & PURITY Moligand™, ≥98%

Synonyms

BCP23933 | BDBM50305877 | 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5h)-one | 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-yl-[1,2]oxazolo[4,5-c]pyridin-4-one | DTXSID90433202 | MMPIP | NCGC00378759-01 | AKOS015851872 | GTPL3341 |

Storage

20°C, 건조 보관

Shipped In

아이스 박스 + 아이스 패드

개요

실온에서 보관하세요. 건조한 곳에 보관하세요. 제품은 최대 12개월까지 보관할 수 있습니다.

Specifications

동의어

BCP23933 | BDBM50305877 | 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5h)-one | 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-yl-[1,2]oxazolo[4,5-c]pyridin-4-one | DTXSID90433202 | MMPIP | NCGC00378759-01 | AKOS015851872 | GTPL3341 |

사양 및 순도

몰리건드™, ≥98%

생화학 및 생리적 메커니즘

MGlu 7 수용체에 대한 강력하고 선택적인 알로스테릭 길항제. 작용제에 의한 세포 내 칼슘 이동 및 cAMP 축적을 억제합니다(IC 50 값은 26 및 610 nM). 또한 내재적 활성을 나타내며, 포스콜린에 의한 cAMP 축적을 증가시킵니다

보관 조건

20°C, 건조 보관

배송

아이스 박스 + 아이스 패드

등급

Moligand™

작업 유형

ALLOSTERIC MODULATOR

작동 메커니즘

Allosteric modulator of mGlu 7 receptor

참고

이 제품은 동결 건조된 한 팩(또는 그 이상) 크기로 제공됩니다. 따라서 내용물이 바이알의 바닥이나 벽을 코팅할 수 있으므로 내용물이 잘 보이지 않을 수 있습니다. 취급에 대한 자세한 내용은 자주 묻는 질문 및 정보 페이지를 참조하세요. 가능하면 당일에 용액을 준비하여 사용하는 것이 좋습니다. 그러나 미리 원액을 만들어야 하는 경우에는 -20°C에서 단단히 밀봉된 바이알에 소량씩 보관하는 것이 좋습니다. 일반적으로 최대 한 달 동안 사용할 수 있습니다. 사용하기 전에 바이알을 열기 전에 제품을 실온에서 최소 1시간 동안 평형을 이루도록 하는 것이 좋습니다. 독성이 있는 경우 자세한 내용은 SDS를 참조하세요. 용해도, 사용법 및 취급에 대한 추가 정보가 필요하신가요? 자세한 내용은 자주 묻는 질문(FAQ) 페이지를 참조하세요.

순수함

≥98%

이름과 식별자

• Pubchem Sid: 504765136
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765136
• 정식 스마일: CN1C(=CC2=C(C1=O)C(=NO2)C3=CC=NC=C3)C4=CC=C(C=C4)OC
• IUPAC Name: 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-yl-[1,2]oxazolo[4,5-c]pyridin-4-one
• InChIKey: PDWYBOZNEVALOV-UHFFFAOYSA-N
• INCHI: 1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3
• 이성체 SMILES: CN1C(=CC2=C(C1=O)C(=NO2)C3=CC=NC=C3)C4=CC=C(C=C4)OC
• 대체 CAS: 1215566-78-1
• 분자량: 333.34
• Reaxy-Rn: 11166762
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11166762&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: Isoxazolopyridines Phenoxy compounds Methoxybenzenes Anisoles Pyridinones Alkyl aryl ethers Isoxazoles Heteroaromatic compounds Lactams Oxacyclic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 2-phenylpyridine - 1,2-oxazolopyridine - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Pyridinone - Monocyclic benzene moiety - Benzenoid - Azole - Isoxazole - Heteroaromatic compound - Lactam - Ether - Oxacycle - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Organic nitrogen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

GRM7 Tchem Metabotropic glutamate receptor 7 (0 Activities)

Discover Target: GRM7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

관련 대상(비인간)

Grm7 Metabotropic glutamate receptor 7 (580 Activities)

Discover Target: Grm7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in DMSO to 10 mM
• 분자량: 333.300 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 333.111 Da
• Monoisotopic Mass: 333.111 Da
• Topological Polar Surface Area: 68.500 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 524.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 479077-02-6, the molecular formula is C19H15N3O3, and the molecular weight is 333.34 g/mol. InChIKey PDWYBOZNEVALOV-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.