Mosloflavone - Moligand™, ≥99% , CAS No.740-33-0

CAS: 740-33-0 Cat. No.: M647485 분자식: C₁₇H₁₄O₅ 분자량: 298.29 PubChem CID: 471722

GRADE & PURITY Moligand™, ≥99%

Synonyms

DTXSID00224789 | AC-34609 | BAICALEIN-6,7-DIMETHYL ETHER | SCHEMBL971985 | ESTRA-1,3,5(10)-TRIENE-3,17-DIOL, 16-(FLUORO-18F)-, (16alpha,17beta)- | SIVAITYPYQQYAP-UHFFFAOYSA-N | FT-0663427 | Mosloflavone | 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-p

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

In Vitro

Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC 50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: EV71,bacterial

Specifications

동의어

DTXSID00224789 | AC-34609 | BAICALEIN-6,7-DIMETHYL ETHER | SCHEMBL971985 | ESTRA-1,3,5(10)-TRIENE-3,17-DIOL, 16-(FLUORO-18F)-, (16alpha,17beta)- | SIVAITYPYQQYAP-UHFFFAOYSA-N | FT-0663427 | Mosloflavone | 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-p

사양 및 순도

Moligand™, ≥99%

생화학 및 생리적 메커니즘

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with xa0anti-EV71 activity. Mosloflavonexa0 inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein s

보관 조건

Protected from light,Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

• Pubchem Sid: 528765650
• 정식 스마일: COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)OC
• IUPAC Name: 5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one
• InChIKey: SIVAITYPYQQYAP-UHFFFAOYSA-N
• INCHI: 1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3
• 이성체 SMILES: COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)OC
• PubChem CID: 471722
• 분자량: 298.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • 분류 Flavonoids
      • Subclass O-methylated flavonoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• 분류: Flavonoids
• Subclass: O-methylated flavonoids
• Intermediate Tree Nodes: Not available
• Direct Parent: 7-O-methylated flavonoids
• Alternative Parents: 6-O-methylated flavonoids Flavones 5-hydroxyflavonoids Chromones Anisoles Pyranones and derivatives Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids Benzene and substituted derivatives Vinylogous acids Heteroaromatic compounds Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 6-methoxyflavonoid-skeleton - 7-methoxyflavonoid-skeleton - 5-hydroxyflavonoid - Flavone - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - Anisole - 1-hydroxy-4-unsubstituted benzenoid - Alkyl aryl ether - Pyranone - Benzenoid - Pyran - Monocyclic benzene moiety - Vinylogous acid - Heteroaromatic compound - Oxacycle - Organoheterocyclic compound - Ether - Organic oxide - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone.
• External Descriptors: Flavones and Flavonols

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

KB 3-1 (1143 Activities)

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MCF7 (126967 Activities)

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H9 (1832 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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KB (17409 Activities)

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관련 대상(비인간)

Staphylococcus aureus (210822 Activities)

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Klebsiella aerogenes (4963 Activities)

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Bacillus sp. (164 Activities)

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Bacillus subtilis (32866 Activities)

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HT-22 (3261 Activities)

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Avian myoblastosis virus polyprotein II (68 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO : 50 mg/mL (167.62 mM; Need ultrasonic)
• 감도: Light sensitive
• 발화점(°F): Not applicable
• 발화점(°C): Not applicable
• 분자량: 298.290 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 298.084 Da
• Monoisotopic Mass: 298.084 Da
• Topological Polar Surface Area: 65.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 440.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1