MSN-50 - ≥98% , CAS No.1592908-75-2

CAS: 1592908-75-2 Cat. No.: M647974 분자식: C₃₆H₃₈BrN₃O₆ 분자량: 688.619 PubChem CID: 154730935

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

개요

MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection

In Vitro

MSN-50 (0~10 uM) inhibits dye release from liposomes in a concentration-dependent fashion. MSN-50 (0~40 uM) inhibits tBid/Bax-mediated MOMP (mitochondrial outer membrane permeabilization) in a concentration-dependent manner and shows concentration-dependent inhibition of Bak-mediated MOMP. MSN-50 inhibits both Bax and Bak after activation by either cBid or Bim. MSN-50 (5 μM; BMK cells) inhibits apoptosis induced by actinomycin D and staurosporin (STS) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Bax Bak

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.

보관 조건

Store at 2-8°C,Argon charged,Desiccated

배송

Wet ice

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

• 정식 스마일: COCCOCOC1=CC2=C(C=C1)C(C(O2)CN(CC3=CC=C(C=C3)Br)C(=O)C(CC4=CC=CC=C4)NC(=O)C5=CC=CC=C5)N
• IUPAC Name: N-[(2S)-1-[[(2R,3S)-3-amino-6-(2-methoxyethoxymethoxy)-2,3-dihydro-1-benzofuran-2-yl]methyl-[(4-bromophenyl)methyl]amino]-1-oxo-3-phenylpropan-2-yl]benzamide
• InChIKey: QRQAGDGLLUPMLV-IGOOQNSHSA-N
• INCHI: 1S/C36H38BrN3O6/c1-43-18-19-44-24-45-29-16-17-30-32(21-29)46-33(34(30)38)23-40(22-26-12-14-28(37)15-13-26)36(42)31(20-25-8-4-2-5-9-25)39-35(41)27-10-6-3-7-11-27/h2-17,21,31,33-34H,18-20,22-24,38H2,1H3,(H,39,41)/t31-,33+,34-/m0/s1
• PubChem CID: 154730935
• 분자량: 688.619

화학 및 물리적 특성

• 용해성: DMSO : 200 mg/mL (290.44 mM; Need ultrasonic)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1592908-75-2, the molecular formula is C36H38BrN3O6, and the molecular weight is 688.619 g/mol. InChIKey QRQAGDGLLUPMLV-IGOOQNSHSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.