PF 06465469 - ≥98% , CAS No.1407966-77-1

CAS: 1407966-77-1 Cat. No.: P288334 분자식: C₃₀H₃₃N₇O₂ 분자량: 523.63 EC 번호: 802-699-5 PubChem CID: 71450146

GRADE & PURITY ≥98%

Synonyms

E98988 | HY-108691 | SCHEMBL22223727 | 1407966-77-1 | AKOS024458306 | Discontinued See A191400 | Discontinued See A191400' | BDBM50399459 | 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benz

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Product description

PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM.

Specifications

동의어

E98988 | HY-108691 | SCHEMBL22223727 | 1407966-77-1 | AKOS024458306 | Discontinued See A191400 | Discontinued See A191400' | BDBM50399459 | 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benz

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50= 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50= 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50va

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

• 정식 스마일: CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCN(C5)C(=O)C=C)C(C)C
• IUPAC Name: 3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benzamide
• InChIKey: CGJVMKJGKFEHTL-HSZRJFAPSA-N
• INCHI: 1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-12,14-15,17-18,23H,1,7,10,13,16H2,2-4H3,(H,34,39)(H2,31,32,33)/t23-/m1/s1
• 이성체 SMILES: CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)[C@@H]5CCCN(C5)C(=O)C=C)C(C)C
• PubChem CID: 71450146
• 분자량: 523.63

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Benzanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides
• Direct Parent: Benzanilides
• Alternative Parents: Phenylpyrazoles Benzamides Pyrazolo[3,4-d]pyrimidines Phenylpropanes Cumenes N-acylpiperidines Benzoyl derivatives Toluenes Aminopyrimidines and derivatives Imidolactams Heteroaromatic compounds Tertiary carboxylic acid amides Acrylic acids and derivatives Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Hydrocarbon derivatives Organic oxides Carbonyl compounds Primary amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzanilide - Phenylpyrazole - Phenylpropane - Pyrazolopyrimidine - N-acyl-piperidine - Cumene - Benzoic acid or derivatives - Benzamide - Pyrazolo[3,4-d]pyrimidine - Benzoyl - Toluene - Aminopyrimidine - Imidolactam - Piperidine - Pyrimidine - Pyrazole - Tertiary carboxylic acid amide - Azole - Heteroaromatic compound - Acrylic acid or derivatives - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Amine - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

ITK Tclin Tyrosine-protein kinase ITK/TSK (2 Activities)

Discover Target: ITK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK (1 Activities)

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (1 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITK Tclin Tyrosine-protein kinase ITK/TSK (3699 Activities)

Discover Target: ITK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BTK Tclin Tyrosine-protein kinase BTK (8973 Activities)

Discover Target: BTK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: Solvent:DMSO, Max Conc. mg/mL: 2.62, Max Conc. mM: 5 with gentle warming
• 분자량: 523.600 g/mol
• XLogP3: 4.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 523.27 Da
• Monoisotopic Mass: 523.27 Da
• Topological Polar Surface Area: 119.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 883.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1