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PROTAC ERα Degrader-9 , CAS No.P1418419
주문 가능
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
PROTAC ERα Degrader-9 (Compound 18c) is a dual-targeting PROTAC degrader, which degrades estrogen receptor α ( ERα ) and aromatase ( ARO ). PROTAC ERα Degrader-9 binds to ERα with a K i of 0.25 μM, inhibits ARO with an IC 50 of 4.6 μM. PROTAC ERα Degrader-9 inhibits the proliferation of MCF-7 wildtype (IC 50 =0.54 μM) and ERα mutants MCF-7 EGFR (IC 50 =0.075 μM), MCF-7 D538G (IC 50 =0.31 μM), MCF-7 Y537S (IC 50 =2.3 μM), downregulates the expressions of ERS1 and MYC. PROTAC ERα Degrader-9 arrests the cell cycle at G2/M, induces apoptosis in MCF-7. PROTAC ERα Degrader-9 exhibits antitumor efficacy in mouse models. (Pink: ligand for target protein ; Black: linker ; Blue: ligand for E3 ligase )
Specifications
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
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작업 유형
DEGRADER
이름과 식별자
| 분자량 | 1124.30 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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리뷰
고객 리뷰
자주 묻는 질문
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is P1418419, the molecular formula is C58H64F3N7O9S2, and the molecular weight is 1124.30 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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