Name: SAR7334 - Moligand™, 10mM in DMSO , Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7, CAS No.1333210-07-3, Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7
SKU: S421260
Availability: InStock

SAR7334 - Moligand™, 10mM in DMSO , Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7, CAS No.1333210-07-3, Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7

CAS: 1333210-07-3 Cat. No.: S421260 분자식: C₂₁H₂₂ClN₃O 분자량: 367.87 PubChem CID: 53378752

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SAR7334 - Moligand™, 10mM in DMSO CAS No(1333210-07-3) by Aladdin Scientific

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주문 가능

GRADE & PURITY Moligand™ ? 10mM in DMSO

Synonyms

Benzonitrile | 4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro | RCP6-IN-1

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요 Specifications 제품 특성 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 솔루션 계산기 리뷰

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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

Information

SAR7334 SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.

Targets

TPRC6 (Cell-free assay) 7.9nM

In vitro

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca(2+) inﬂux into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected..SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice.

In vivo

Pharmacokinetic studies of SAR7334 demonstrates that the compound was suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).

Cell Research(from reference)

Cell lines：HEK cells

Specifications

동의어

Benzonitrile | 4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro | RCP6-IN-1

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

CHANNEL BLOCKER

작동 메커니즘

Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7

제품 특성

ALogP	3.871
HBD 수	1
회전 가능한 결합	3

이름과 식별자

Pubchem Sid	528767026
정식 스마일	C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N
IUPAC Name	4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile
InChIKey	RLKRLNQEXBPQGQ-OZOXKJRCSA-N
INCHI	1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-/m1/s1
이성체 SMILES	C1C[C@H](CN(C1)[C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(C=C(C=C4)C#N)Cl)N
PubChem CID	53378752
분자량	367.87

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 분류 Indanes

Kingdom	Organic compounds
Superclass	Benzenoids
분류	Indanes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Indanes
Alternative Parents	Phenoxy compounds Phenol ethers Benzonitriles Chlorobenzenes Aralkylamines Aminopiperidines Alkyl aryl ethers Aryl chlorides Trialkylamines Nitriles Azacyclic compounds Organopnictogen compounds Organochlorides Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Indane - Phenoxy compound - Benzonitrile - Phenol ether - Alkyl aryl ether - 3-aminopiperidine - Aralkylamine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Piperidine - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organoheterocyclic compound - Ether - Carbonitrile - Nitrile - Primary aliphatic amine - Organooxygen compound - Primary amine - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Cyanide - Organopnictogen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

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리뷰

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Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

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DMSO(mg/mL) 최대 용해도	74
DMSO(mM) 최대 용해도	201.158017778019
물(mg/mL) 최대 용해도	＜1
분자량	367.900 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	367.145 Da
Monoisotopic Mass	367.145 Da
Topological Polar Surface Area	62.300 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	535.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1