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· · COA & SDS 모든 제품에 대한 사용 가능 · 주식 상품에 대한 같은 날 배송 SPP 86 - ≥98%(HPLC) , CAS No.1357349-91-7
Synonyms
SPP8|1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine|1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine|SPP86
Shipped In
Ice chest + Ice pads
사양 동의어
SPP8 | 1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | SPP86
생화학 및 생리적 메커니즘
SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated act
배송
Ice chest + Ice pads
이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.
이름과 식별자 정식 스마일
CC(C)N1C2=NC=NC(=C2C(=N1)C#CC3=CC=CC=C3)N
IUPAC Name
3-(2-phenylethynyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
InChIKey
JQOIRTDBHMDWMT-UHFFFAOYSA-N
INCHI
1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
이성체 SMILES
CC(C)N1C2=NC=NC(=C2C(=N1)C#CC3=CC=CC=C3)N
고급 데이터 Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds 분류 Pyrazolopyrimidines Subclass Pyrazolo[3,4-d]pyrimidines Intermediate Tree Nodes Not available Direct Parent Pyrazolo[3,4-d]pyrimidines Alternative Parents Aminopyrimidines and derivatives Imidolactams Benzene and substituted derivatives Pyrazoles Heteroaromatic compounds Azacyclic compounds Primary amines Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Pyrazolo[3,4-d]pyrimidine - Aminopyrimidine - Monocyclic benzene moiety - Pyrimidine - Benzenoid - Imidolactam - Pyrazole - Azole - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Primary amine - Organonitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound 설명 This compound belongs to the class of organic compounds known as pyrazolo[3,4-d]pyrimidines. These are aromatic heterocyclic compounds containing a pyrazolo[3,4-d]pyrimidine ring system, which consists of a pyrazole ring fused to but and not sharing a nitrogen atom with a pyrimidine ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 용해성 Solvent:DMSO, Max Conc. mg/mL: 27.73, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.55, Max Conc. mM: 20 분자량 277.320 g/mol XLogP3 2.600 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 3 Exact Mass 277.133 Da Monoisotopic Mass 277.133 Da Topological Polar Surface Area 69.600 Ų Heavy Atom Count 21 Formal Charge 0 Complexity 417.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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