Squarunkin A - ≥99% , CAS No.2101958-02-3

CAS: 2101958-02-3 Cat. No.: S649430 분자식: C₂₅H₃₂F₃N₅O₄ 분자량: 523.55 PubChem CID: 134611887

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A -myristoylated Src N-terminal peptide interaction ( IC 50 =10 nM). Squarunkin A interferes with the activation of Src kinase in cells

In Vitro

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation. Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A -myristoylated Src N-terminal peptide interaction ( IC 50 =10 nM). Squarunkin A interferes with the activation of Src kinase in cells.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥99%

이름과 식별자

• 정식 스마일: CCOC(=O)N1CCC(CC1)NC2=C(C(=O)C2=O)NCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
• IUPAC Name: ethyl 4-[[3,4-dioxo-2-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethylamino]cyclobuten-1-yl]amino]piperidine-1-carboxylate
• InChIKey: ZKITWOVRRSBKFG-UHFFFAOYSA-N
• INCHI: 1S/C25H32F3N5O4/c1-2-37-24(36)33-9-6-18(7-10-33)30-21-20(22(34)23(21)35)29-8-11-31-12-14-32(15-13-31)19-5-3-4-17(16-19)25(26,27)28/h3-5,16,18,29-30H,2,6-15H2,1H3
• PubChem CID: 134611887
• 분자량: 523.55

화학 및 물리적 특성

• 용해성: DMSO : 9.62 mg/mL (18.37 mM; ultrasonic and warming and heat to 60°C)
• 분자량: 523.500 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 9
• Exact Mass: 523.241 Da
• Monoisotopic Mass: 523.241 Da
• Topological Polar Surface Area: 94.200 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 880.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2101958-02-3, the molecular formula is C25H32F3N5O4, and the molecular weight is 523.55 g/mol. InChIKey ZKITWOVRRSBKFG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.