10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
UPF 1069 is a selectivePARP2inhibitor withIC50of 0.3 μM. It is ~27-fold selective against PARP1.
In vitro
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM.
In vivo
In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| 이성체 SMILES | C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O |
|---|---|
| PubChem CID | 25015515 |
| 분자량 | 279.29 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 날짜 | 항목 |
|---|---|---|---|
 H2408030 | Certificate of Analysis | Jun 03, 2026 | U408511 |
| 용해성 | Solubility (25°C) In vitro DMSO: 81 mg/mL (199.08 mM); Water: 81 mg/mL (199.08 mM); Ethanol: 81 mg/mL (199.08 mM); |
|---|---|
| 굴절률 | 1.62 |
| 끓는점(°C) | ~570.3 °C at 760 mmHg |
| 녹는점(°C) | 166-168°C |
