VU6012962 - 10mM in DMSO , CAS No.2313526-86-0

CAS: 2313526-86-0 Cat. No.: V656429 분자식: C₂₁H₁₉F₃N₄O₄ 분자량: 448.40

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nM

In Vitro

VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6J male mice (8 weeks old) Dosage: 1, 3, and 10 mg/kg Administration: I.p. injections; 60 minutes prior to testing Result: Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.

IC50& Target:mGlu7 347 nM (IC 50 )

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 이성체 SMILES: COC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
• 분자량: 448.40