VUF 10166 - 10mM in DMSO , CAS No.155584-74-0

CAS: 155584-74-0 Cat. No.: V407864 분자식: C₁₃H₁₅ClN₄ 분자량: 262.74 PubChem CID: 24278976

GRADE & PURITY 10mM in DMSO

Synonyms

Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

VUF10166 is a novel, potent and competitive antagonist for5-HT3Areceptor withKiof 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
In vitro

VUF10166 shows low activity to 5-HT₃AB receptor with K_i of 22 nM. VUF10166 may be used to can distinguish between 5-HT₃A and 5-HT₃AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

동의어

Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with K_i of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 이성체 SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl
• PubChem CID: 24278976
• 분자량: 262.74

관련 대상(인간)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (1 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 36 mg/mL (199.7 mM); Ethanol: 7 mg/mL (38.83 mM); Water: Insoluble

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 155584-74-0, the molecular formula is C13H15ClN4, and the molecular weight is 262.74 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.