Miosina IIA

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  1. N8-[(2S)-3,3-dimethylbutan-2-yl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine, Inhibitor of TTK protein kinase
    CAS: 1578244-34-4 Fórmula: C24H29N7O Peso molecular: 431.5334
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ◐ .Sob encomenda · 8–12 semanas Item #: N174563
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    Nome IUPAC
    8-N-[(2S)-3,3-dimethylbutan-2-yl]-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
    SMILES
    CC(C(C)(C)C)NC1=NC=CC2=CN=C(N=C21)NC3=C(C=C(C=C3)C4=CN(N=C4)C)OC
    InChIKey
    XTJZKALDRPVFSN-HNNXBMFYSA-N
    InChI
    1S/C24H29N7O/c1-15(24(2,3)4)28-22-21-17(9-10-25-22)12-26-23(30-21)29-19-8-7-16(11-20(19)32-6)18-13-27-31(5)14-18/h7-15H,1-6H3,(H,25,28)(H,26,29,30)/t1show more
  2. Mps1-IN-1 dihydrochloride
    CAS: 1883548-93-3 PubChem CID: 91691119 Fórmula: C28H33N5O4S.2HCl Peso molecular: 608.58
    ◐ .Sob encomenda · 8–12 semanas Item #: M287223
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    Nome IUPAC
    1-[3-methoxy-4-[[4-(2-propan-2-ylsulfonylanilino)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]piperidin-4-ol;dihydrochloride
    SMILES
    CC(C)S(=O)(=O)C1=CC=CC=C1NC2=CC(=NC3=C2C=CN3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC.Cl.Cl
    InChIKey
    HFJLUXGXTPNYTQ-UHFFFAOYSA-N
    InChI
    1S/C28H33N5O4S.2ClH/c1-18(2)38(35,36)26-7-5-4-6-23(26)30-24-17-27(32-28-21(24)10-13-29-28)31-22-9-8-19(16-25(22)37-3)33-14-11-20(34)12-15-33;;/h4-10,1show more
    Sinónimos
    1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidin...
  3. AZ 3146, Inhibitor of TTK protein kinase
    CAS: 1124329-14-1 Fórmula: C24H32N6O3 Peso molecular: 452.55
    Sólido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — EUA Item #: A127268
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    Nome IUPAC
    9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one
    SMILES
    CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
    InChIKey
    YUKWVHPTFRQHMF-UHFFFAOYSA-N
    InChI
    1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,show more
    Sinónimos
    AKOS024457919 | SW219317-1 | HY-14710 | CCG-264989 | AZ3146 | AZ-3146 | 9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperid...
  4. TC Mps1 12
    CAS: 1206170-62-8 PubChem CID: 70682875 Fórmula: C17H20N6O Peso molecular: 324.38
    ● Em estoque — EUA Item #: T287052
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    Nome IUPAC
    4-[[4-amino-6-(tert-butylamino)-5-cyanopyridin-2-yl]amino]benzamide
    SMILES
    CC(C)(C)NC1=C(C(=CC(=N1)NC2=CC=C(C=C2)C(=O)N)N)C#N
    InChIKey
    XDEFNAWAKYQBQY-UHFFFAOYSA-N
    InChI
    1S/C17H20N6O/c1-17(2,3)23-16-12(9-18)13(19)8-14(22-16)21-11-6-4-10(5-7-11)15(20)24/h4-8H,1-3H3,(H2,20,24)(H4,19,21,22,23)
    Sinónimos
    4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
  5. BAY 1217389, Dual specificity protein kinase TTK inhibitor
    CAS: 1554458-53-5 Fórmula: C27H24F5N5O3 Peso molecular: 561.50
    10mM in DMSO
    ● Em estoque — EUA Item #: B421851
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    Nome IUPAC
    N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-(3,3,3-trifluoropropylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
    SMILES
    CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5
    InChIKey
    WNEILUNVMHVMPH-UHFFFAOYSA-N
    InChI
    1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,show more
    Sinónimos
    AKOS032944938 | AC-36064 | HY-12859 | NSC787026 | NSC-787026 | BAY1217389 | BAY-1217389 | GTPL12705 | M964LB1114 | EX...
  6. BAY 1217389, Dual specificity protein kinase TTK inhibitor
    CAS: 1554458-53-5 Fórmula: C27H24F5N5O3 Peso molecular: 561.50
    Sólido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● Em estoque — EUA Item #: B413947
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    Nome IUPAC
    N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-(3,3,3-trifluoropropylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
    SMILES
    CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5
    InChIKey
    WNEILUNVMHVMPH-UHFFFAOYSA-N
    InChI
    1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,show more
    Sinónimos
    AKOS032944938 | AC-36064 | HY-12859 | NSC787026 | NSC-787026 | BAY1217389 | BAY-1217389 | GTPL12705 | M964LB1114 | EX...
  7. BOS172722
    CAS: 1578245-44-9 Fórmula: C24H30N8O Peso molecular: 446.55
    10mM in DMSO
    ◐ .Sob encomenda · 8–12 semanas Item #: B421892
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    Nome IUPAC
    8-N-(2,2-dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine
    SMILES
    CCOC1=C(C=CC(=C1)C2=NN=CN2C)NC3=NC=C4C=C(N=C(C4=N3)NCC(C)(C)C)C
    InChIKey
    SGWLRDAOCLITOM-UHFFFAOYSA-N
    InChI
    1S/C24H30N8O/c1-7-33-19-11-16(22-31-27-14-32(22)6)8-9-18(19)29-23-25-12-17-10-15(2)28-21(20(17)30-23)26-13-24(3,4)5/h8-12,14H,7,13H2,1-6H3,(H,26,28)(Hshow more
    Sinónimos
    compound 36 [PMID: 30199249] | s8911 | 1578245-44-9 | N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl...
  8. BOS172722
    CAS: 1578245-44-9 Fórmula: C24H30N8O Peso molecular: 446.55
    ● Em estoque — EUA Item #: B414264
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    Nome IUPAC
    8-N-(2,2-dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine
    SMILES
    CCOC1=C(C=CC(=C1)C2=NN=CN2C)NC3=NC=C4C=C(N=C(C4=N3)NCC(C)(C)C)C
    InChIKey
    SGWLRDAOCLITOM-UHFFFAOYSA-N
    InChI
    1S/C24H30N8O/c1-7-33-19-11-16(22-31-27-14-32(22)6)8-9-18(19)29-23-25-12-17-10-15(2)28-21(20(17)30-23)26-13-24(3,4)5/h8-12,14H,7,13H2,1-6H3,(H,26,28)(Hshow more
    Sinónimos
    compound 36 [PMID: 30199249] | s8911 | 1578245-44-9 | N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl...
  9. Empesertib (BAY1161909), Dual specificity protein kinase TTK inhibitor
    CAS: 1443763-60-7 Fórmula: C29H26FN5O4S Peso molecular: 559.61
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — EUA Item #: E413946
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    Nome IUPAC
    (2R)-2-(4-fluorophenyl)-N-[4-[2-(2-methoxy-4-methylsulfonylanilino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide
    SMILES
    CC(C1=CC=C(C=C1)F)C(=O)NC2=CC=C(C=C2)C3=CN4C(=NC(=N4)NC5=C(C=C(C=C5)S(=O)(=O)C)OC)C=C3
    InChIKey
    NRJKIOCCERLIDG-GOSISDBHSA-N
    InChI
    1S/C29H26FN5O4S/c1-18(19-4-9-22(30)10-5-19)28(36)31-23-11-6-20(7-12-23)21-8-15-27-33-29(34-35(27)17-21)32-25-14-13-24(40(3,37)38)16-26(25)39-2/h4-18H,show more
    Sinónimos
    A908652 | (-)-BAY-1161909 | Benzeneacetamide, 4-fluoro-N-[4-[2-[[2-methoxy-4-(methylsulfonyl)phenyl]amino][1,2,4]tria...
  10. MPI-0479605, Inhibitor of TTK protein kinase
    CAS: 1246529-32-7 Fórmula: C22H29N7O Peso molecular: 407.51
    Sólido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — EUA Item #: M413761
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    Nome IUPAC
    6-N-cyclohexyl-2-N-(2-methyl-4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
    SMILES
    CC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C(=N3)NC5CCCCC5)NC=N4
    InChIKey
    OVJBNYKNHXJGSA-UHFFFAOYSA-N
    InChI
    1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,show more
    Sinónimos
    N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
  11. MPI-0479605, Inhibitor of TTK protein kinase
    CAS: 1246529-32-7 Fórmula: C22H29N7O Peso molecular: 407.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● Em estoque — EUA Item #: M421046
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    Nome IUPAC
    6-N-cyclohexyl-2-N-(2-methyl-4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
    SMILES
    CC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C(=N3)NC5CCCCC5)NC=N4
    InChIKey
    OVJBNYKNHXJGSA-UHFFFAOYSA-N
    InChI
    1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,show more
    Sinónimos
    N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
  12. luvixasertib, Inhibitor of TTK protein kinase
    CAS: 1610759-22-2 PubChem CID: 118086034
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Sob encomenda · 8–12 semanas Item #: L611619
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    Nome IUPAC
    N-cyclopropyl-4-[7-[(3-hydroxy-3-methylcyclobutyl)methylamino]-5-pyridin-3-yloxypyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzamide
    SMILES
    Cc1c(ccc(c1)c1c2nc(cc(n2nc1)NCC1CC(C1)(C)O)Oc1cnccc1)C(=O)NC1CC1
    InChIKey
    PMQUGSPFUBGJCZ-UHFFFAOYSA-N
    InChI
    1S/C28H30N6O3/c1-17-10-19(5-8-22(17)27(35)32-20-6-7-20)23-16-31-34-24(30-14-18-12-28(2,36)13-18)11-25(33-26(23)34)37-21-4-3-9-29-15-21/h3-5,8-11,15-16show more
    Sinónimos
    SCHEMBL16729234 | EX-A2577 | CARD-20(22)-ENOLIDE, 3-((6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)OXY)-1,5,11,14,19-PENTAHYDROXY...
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Perguntas frequentes

Which compounds are listed for Mps1?
Compounds associated with Mps1 are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Mps1 sit within Cell Cycle/DNA Damage?
Mps1 is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Mps1?
For compounds listed under Mps1, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Mps1?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring Mps1, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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