12-OxoETE - 100 ug/mL in ethanol，≥90% , CAS No.108437-64-5

CAS: 108437-64-5 Cat. No.: O348448 Summenformel: C₂₀H₃₀O₃ Molekulargewicht: 318.5 PubChem CID: 5283162

GRADE & PURITY 100 ug/mL in ethanol，≥90%

Synonyms

12-keto-ETE | DTXSID00390599 | SCHEMBL21114414 | PD018254 | 12-oxo, 5c,8c,10t,14c-20:4 | 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid | 12-KETE | (5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoate | SR-01000946927-1 | SR-01000946927 | 5,8,10,14-Eicosatetrae

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

12-OxoETE is synthesized by human platelets and|Aplysia|nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via an Leukotriene B4 receptor or a common activation sequence.

Specifications

Synonyme

12-keto-ETE | DTXSID00390599 | SCHEMBL21114414 | PD018254 | 12-oxo, 5c,8c,10t,14c-20:4 | 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid | 12-KETE | (5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoate | SR-01000946927-1 | SR-01000946927 | 5,8,10,14-Eicosatetrae

Spezifikationen & Reinheit

100 ug/mL in ethanol，≥90%

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Kanonisches Lächeln

CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O

IUPAC Name

(5Z,8Z,10E,14Z)-12-oxoicosa-5,8,10,14-tetraenoic acid

InChIKey

GURBRQGDZZKITB-VXBMJZGYSA-N

INCHI

1S/C20H30O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+

Isomere SMILES

CCCCC/C=C\CC(=O)/C=C/C=C\C/C=C\CCCC(=O)O

PubChem CID

5283162

Molekulargewicht

318.5

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Klasse Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Klasse: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Unsaturated fatty acids Enones Acryloyl compounds Ketones Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Long-chain fatty acid - Unsaturated fatty acid - Alpha,beta-unsaturated ketone - Enone - Acryloyl-group - Ketone - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: Hydroxy/hydroperoxyeicosatetraenoic acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

Discover Target: ALOX5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

Discover Target: ALOX12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

Discover Target: ALOX15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water (0.8 mg/ml at 25° C), ethanol, DMSO, DMF, and PBS pH 7.2, sol. (~0.8).
• Brechungsindex: n20D1.51 (Predicted)
• Siedepunkt (°C): 78° C
• Molekulargewicht: 318.400 g/mol
• XLogP3: 5.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 14
• Exact Mass: 318.219 Da
• Monoisotopic Mass: 318.219 Da
• Topological Polar Surface Area: 54.400 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 428.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 108437-64-5, the molecular formula is C20H30O3, and the molecular weight is 318.5 g/mol. InChIKey GURBRQGDZZKITB-VXBMJZGYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.