2,4-Diaminotoluene - CP , CAS No.95-80-7

CAS: 95-80-7 Cat. No.: D103648 Molecular Weight: 122.17 Beilstein Registry Number: 13124 EC Number: 202-453-1
AVAILABLE TO ORDER
GRADE & PURITY CP ? Chemically Pure grade — moderate purity above technical grade but below analytical. Use for general lab reactions where ultra-low impurities aren't critical.
Synonyms
4-methyl-benzene-1,3-diamine | 4-methylbenzene-1,3-diamine | Fouramine | STK941128 | toluylendiamin | 2,4-Diaminotoluol | Eucanine GB | TOLUENE-2,4-DIAMINE [HSDB] | AC-14889 | Benzofur MT | D89597 | EN300-18287 | AI3-03717 | C.I. Oxidation Base 35 | 1,3-D
Storage
Room temperature
Shipped In
FedEx DG Service
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
100g
D103648-100g
5
$19.90
500g
D103648-500g
1
$69.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

CP CP for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
4-methyl-benzene-1, 3-diamine | 4-methylbenzene-1, 3-diamine | Fouramine | STK941128 | toluylendiamin | 2, 4-Diaminotoluol | Eucanine GB | TOLUENE-2, 4-DIAMINE [HSDB] | AC-14889 | Benzofur MT | D89597 | EN300-18287 | AI3-03717 | C.I. Oxidation Base 35 | 1, 3-D
Specifications & Purity
CP
Storage
Room temperature
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
CP
Names and Identifiers
Pubchem Sid488180362
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180362
Canonical SmilesCC1=C(C=C(C=C1)N)N
IUPAC Name4-methylbenzene-1,3-diamine
InChIKeyVOZKAJLKRJDJLL-UHFFFAOYSA-N
INCHI1S/C7H10N2/c1-5-2-3-6(8)4-7(5)9/h2-4H,8-9H2,1H3
Isomeric SMILES CC1=C(C=C(C=C1)N)N
RTECS XS9625000
UN Number 1709(solid)3418(solution)
Packing Group III
Molecular Weight 122.17
Beilstein 13124
Reaxy-Rn 2205839
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2205839&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassToluenes
Intermediate Tree Nodes Aminotoluenes
Direct ParentDiaminotoluenes
Alternative Parents Aniline and substituted anilines  Primary amines  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Diaminotoluene - Aniline or substituted anilines - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as diaminotoluenes. These are organic aromatic compounds containing a benzene that carries a single methyl group exactly 2 amino groups.
External Descriptors aminotoluene
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
AHR Tclin Aryl hydrocarbon receptor (1071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
C2609417Certificate of AnalysisMar 28, 2026 D103648
C2609430Certificate of AnalysisMar 28, 2026 D103648
C2609476Certificate of AnalysisMar 28, 2026 D103648
L2106328Certificate of AnalysisSep 09, 2025 D103648
L2106571Certificate of AnalysisSep 09, 2025 D103648
L2106573Certificate of AnalysisSep 09, 2025 D103648
J2108009Certificate of AnalysisJul 10, 2025 D103648
G2123083Certificate of AnalysisMay 09, 2025 D103648
E2324725Certificate of AnalysisMay 31, 2023 D103648
B2306984Certificate of AnalysisFeb 09, 2023 D103648
K2422253Certificate of AnalysisJul 28, 2021 D103648

Show more ⌵

Chemical and Physical Properties
SensitivityMoisture sensitive.
Boil Point(°C)280°C
Melt Point(°C)99°C
Molecular Weight122.170 g/mol
XLogP30.100
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass122.084 Da
Monoisotopic Mass122.084 Da
Topological Polar Surface Area52.000 Ų
Heavy Atom Count9
Formal Charge0
Complexity92.900
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Xing Liu, Zhenhong Xiao, Xianyong Liu, Yuling Liu, Jianqing Zhao, Shumei Liu.  (2023)  Design and synthesis of epoxy prepolymer containing aromatic imide structures for thermoset with excellent thermal, mechanical and dielectric properties.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2023.119149]
2. Yu-Fei Li, Can-Jun Zou, Xing-Biao Liu, Feng Gan, Ping-Ping Fang.  (2023)  Highly Sensitive and Selective Detection of Pharmaceuticals on Au/MIL-101(Cr) by SERS.  ANALYTICAL CHEMISTRY,      [PMID:37159411] [10.1021/acs.analchem.3c00466]
3. Liyan Chen, Meng Rong, Jiemiao Yu, Qiyu Meng, Shan Ni, Xia Wu, Li Wang, Huifang Xing, Huizhou Liu, Liangrong Yang.  (2023)  Highly efficient removal of aromatic diamines from the polyurethane bio-hydrolysate by MIL-53 series MOFs.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.141326]
4. Xu Qilin, Li Guosi, Zhu Fucheng, Chen Naidong, Chen Cuiwu, Yu Zhiqun.  (2022)  Continuous synthesis of N-(3-Amino-4-methylphenyl)benzamide and its kinetics study in microflow system.  Journal of Flow Chemistry,  12  (3): (317-325).  [PMID:] [10.1007/s41981-022-00241-1]
5. Feng Lang, Yu Xiang, Chunguang Xiao, Duxin Li.  (2022)  Preparation and properties of ODPA-ODA-SDA polyimide film and its application in corona resistance.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2022.106777]
6. Liyan Chen, Meng Rong, Liangrong Yang, Jiemiao Yu, Hongnan Qu, Qiyu Meng, Shan Ni, Zihao Xu, Xiangyang Zhu, Li Wang, Huifang Xing, Huizhou Liu.  (2021)  Construction of super-hydrophobic hypercrosslinked porous polymers for selectively removing aromatic diamines from the polyurethane bio-hydrolysate.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2021.132509]
7. Can Chen, Guotong Ruan, Yujie Sun, Lili Wang, Chengwu Zhang, Jinhua Liu.  (2021)  In situ Cu2+-triggered wavelength-tunable fluorescent sensor for highly sensitive sensing inorganic pyrophosphatase activity and its logic gate application.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.130439]
8. Jie Gao, Yanfeng Liu, Bo Jiang, Wenmin Cao, Yansheng Kan, Wei Chen, Meng Ding, Guiyang Zhang, Bowen Zhang, Kai Xi, Xudong Jia, Xiaozhi Zhao, Hongqian Guo.  (2020)  Phenylenediamine-Based Carbon Nanodots Alleviate Acute Kidney Injury via Preferential Renal Accumulation and Antioxidant Capacity.  ACS Applied Materials & Interfaces,      [PMID:32571010] [10.1021/acsami.0c05041]
9. Huilin Gou, Yanfeng Liu, Guiyang Zhang, Qiaobo Liao, Xin Huang, Fangyi Ning, Can Ke, Zhen Meng, Kai Xi.  (2019)  Lifetime-tunable room-temperature phosphorescence of polyaniline carbon dots in adjustable polymer matrices.  Nanoscale,  11  (39): (18311-18319).  [PMID:31573008] [10.1039/C9NR05561D]
10. Yanfeng Liu, Yin Ding, Huilin Gou, Xin Huang, Guiyang Zhang, Qi Zhang, Yunzhong Liu, Zhen Meng, Kai Xi, Xudong Jia.  (2018)  Room temperature synthesis of pH-switchable polyaniline quantum dots as a turn-on fluorescent probe for acidic biotarget labeling.  Nanoscale,  10  (14): (6660-6670).  [PMID:29582868] [10.1039/C8NR00381E]
11. Hui Han, Shusheng Li, Xiaoli Zhu, Xubao Jiang, Xiang Zheng Kong.  (2014)  One step preparation of porous polyurea by reaction of toluene diisocyanate with water and its characterization.  RSC Advances,  (63): (33520-33529).  [PMID:] [10.1039/C4RA06383J]
12. Yucong Song, Mingchuan Pang, Xiaoshu Ding, Guirong Wang, Xinqiang Zhao, Yanji Wang.  (2024)  Determination of the solubility, dissolution enthalpy and entropy of 2,4-diaminotoluene, methyl 3-amino-4-methyl-N-phenyl carbamate and dimethyl toluene-2,4-dicarbamate in different solvents.  JOURNAL OF CHEMICAL THERMODYNAMICS,      [PMID:] [10.1016/j.jct.2024.107261]
13. Wei Xia, Haohong Lin, Xinyu Zhou, Yihu Wang, Shixiang Cao, Jiawei Liu, Anming Xu, Weiliang Dong, Min Jiang.  (2024)  Screening of polyurethane-degrading microbes using a quenching fluorescence probe by microfluidic droplet sorting.  CHEMOSPHERE,      [PMID:39121966] [10.1016/j.chemosphere.2024.143060]
14. Jiexun Huang, Guojing Ning, Feili Li, G. Daniel Sheng.  (2015)  Biotransformation of 2,4-dinitrotoluene by obligate marine Shewanella marisflavi EP1 under anaerobic conditions.  BIORESOURCE TECHNOLOGY,      [PMID:25603529] [10.1016/j.biortech.2014.12.108]
15. Yujie Wang, Keyu Chen, Guodong Cheng, Sitian Du, Fei Wang.  (2025)  Electroanalytical approach for the detection of 2,4-diaminotoluene based on electrochemically reduced graphene oxide-carboxylic single walled carbon nanotubes.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D5NJ00053J]
16. Huanhuan Yang, Wenxin Xu, Lanting Xie, Han Wang, Xuhui Fang, Jian Qi, Jie Wang, Pan Hu, Sihui Zhan, Shuanglong Ma, Boqiang Gao.  (2025)  Efficient adsorption of trimethoprim on carboxymethyl lignin-based three-dimensional porous sponges: Qualitative and quantitative analysis of multiple interactions.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171113]
17. Chunhui Bi, Congzhen Xie, Qingyu Wang, Daoming Zhang, An Zhong, Hangchuan Cai, Yongxia Han, Jing Fu, Qi Li, Rui Wang.  (2026)  Polymer dielectrics with customized substituent for high temperature capacitive energy storage.  Energy Storage Materials,      [PMID:] [10.1016/j.ensm.2026.104945]
18. Li Bohui, Liu Wei, Song Yucong, Ding Xiaoshu, Wang Yanji.  (2026)  Catalytic hydrogenation of 2,4-dinitrotoluene to 2,4-toluenediamine using isopropanol as hydrogen source.  RESEARCH ON CHEMICAL INTERMEDIATES,      [PMID:] [10.1007/s11164-026-05962-9]
Solution Calculators
Reviews

Customer Reviews

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View CP grade guide →

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.