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for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity.
| Canonical Smiles | CP(=O)([O-])OCCN.C(=O)(C(F)(F)F)O |
|---|---|
| IUPAC Name | 2-aminoethoxy(methyl)phosphinate;2,2,2-trifluoroacetic acid |
| InChIKey | RFQBFVSSBOQLIQ-UHFFFAOYSA-M |
| INCHI | 1S/C3H10NO3P.C2HF3O2/c1-8(5,6)7-3-2-4;3-2(4,5)1(6)7/h2-4H2,1H3,(H,5,6);(H,6,7)/p-1 |
| Isomeric SMILES | CP(=O)([O-])OCCN.C(=O)(C(F)(F)F)O |
| Alternate CAS | 321882-95-5 |
| PubChem CID | 154701392 |
| Molecular Weight | 252.11 |
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