2-Aminothiazole - ≥97% , CAS No.96-50-4

CAS: 96-50-4 Cat. No.: A104872 Summenformel: C₃H₄N₂S Molekulargewicht: 100.14 Beilstein Registry Number: 105738 EG-Nummer: 202-511-6

GRADE & PURITY ≥97%

Synonyms

2-Amino-1,3-thiazole | AKOS000119189 | Aminothiazol | CHEBI:40782 | Thiazol-2-ylamine | thiazol-2-yl-amine | thiazolyl amine | 2-imino-2,3-dihydro-1,3-thiazole | DivK1c_000176 | KBio2_000505 | thiazol-2-amine | HY-12396 | SCHEMBL7401 | 2-amino-1,3 thiazol

Storage

Protected from light,Room temperature,Argon charged

Shipped In

Normal

Übersicht

Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.

Specifications

Synonyme

2-Amino-1,3-thiazole | AKOS000119189 | Aminothiazol | CHEBI:40782 | Thiazol-2-ylamine | thiazol-2-yl-amine | thiazolyl amine | 2-imino-2,3-dihydro-1,3-thiazole | DivK1c_000176 | KBio2_000505 | thiazol-2-amine | HY-12396 | SCHEMBL7401 | 2-amino-1,3 thiazol

Spezifikationen & Reinheit

≥97%

Biochemische und physiologische Mechanismen

2-Aminothiazole is a potent cyclin-dependent kinase 5 inhibitor and is a therapeutic drug for Alzheimer's disease and other neurodegenerative diseases.

Storage

Protected from light,Room temperature,Argon charged

Verschickt in

Normal

Reinheit

≥97%

Namen und Kennungen

Pubchem Sid

488179668

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488179668

Kanonisches Lächeln

C1=CSC(=N1)N

IUPAC Name

1,3-thiazol-2-amine

InChIKey

RAIPHJJURHTUIC-UHFFFAOYSA-N

INCHI

1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)

Isomere SMILES

C1=CSC(=N1)N

WGK Deutschland

3

RTECS

XJ2100000

Alternative CAS-Nummer

6142-05-8

Molekulargewicht

100.14

Beilstein

105738

Reaxy-Rn

105738

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105738&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Azoles
      • Subclass Thiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Azoles
• Subclass: Thiazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Thiazoles
• Alternative Parents: Heteroaromatic compounds Isothioureas Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Heteroaromatic compound - Thiazole - Isothiourea - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as thiazoles. These are heterocyclic compounds containing a five-member aromatic ring made up of one sulfur atom, one nitrogen, and three carbon atoms.
• External Descriptors: 1,3-thiazole - primary amino compound

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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MAOB Tclin Monoamine oxidase B (8835 Activities)

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PRKAA2 Tchem AMP-activated protein kinase, alpha-2 subunit (1328 Activities)

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NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

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ddlB D-alanylalanine synthetase (66 Activities)

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murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (389 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Salmonella typhimurium (15756 Activities)

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Plasmodium falciparum (966862 Activities)

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Cavia porcellus (23802 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Plasma (328 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water, alcohol and ether
• Empfindlichkeit: Light Sensitive,Air Sensitive
• Siedepunkt (°C): 117°C
• Schmelzpunkt (°C): 93°C
• Molekulargewicht: 100.140 g/mol
• XLogP3: 0.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 100.01 Da
• Monoisotopic Mass: 100.01 Da
• Topological Polar Surface Area: 67.200 Ų
• Heavy Atom Count: 6
• Formal Charge: 0
• Complexity: 48.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1