3-AP-Me , CAS No.1184391-57-8

CAS: 1184391-57-8 Cat. No.: A1416536 Molecular Weight: 223.3 EC Number: 808-469-0 PubChem CID: 44235406

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Overview

3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6 , leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase ( JNK ) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Names and Identifiers

• Canonical Smiles: CN(C)C(=S)NN=CC1=C(C=CC=N1)N
• IUPAC Name: 3-[(E)-(3-aminopyridin-2-yl)methylideneamino]-1,1-dimethylthiourea
• InChIKey: DQVSEUUIXQTWRB-WUXMJOGZSA-N
• INCHI: 1S/C9H13N5S/c1-14(2)9(15)13-12-6-8-7(10)4-3-5-11-8/h3-6H,10H2,1-2H3,(H,13,15)/b12-6+
• Isomeric SMILES: CN(C)C(=S)N/N=C/C1=C(C=CC=N1)N
• WGK Germany: 3
• PubChem CID: 44235406
• Molecular Weight: 223.3