3-Chlorophenol - analytical standard , CAS No.108-43-0

CAS: 108-43-0 Cat. No.: C104276 Molecular Weight: 128.56 Beilstein Registry Number: 1634401 EC Number: 203-582-6
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GRADE & PURITY Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods.
Synonyms
m-Chlorophenol | m-chloro-phenol | 3-Hydroxychlorobenzene | EINECS 203-582-6 | NCGC00091698-02 | 3-CHLOROPHENOL [HSDB] | M-CHLOROPHENOL [MI] | 3-chloro phenol | PS-6042 | 3-Chloro-1-hydroxybenzene | m-Chlorophenol, solid | Z2Z7M2FTAD | 3CH | BDBM50167952
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250mg
C104276-250mg
3

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Why this grade

analytical standard Analytical standard for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 43 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
m-Chlorophenol | m-chloro-phenol | 3-Hydroxychlorobenzene | EINECS 203-582-6 | NCGC00091698-02 | 3-CHLOROPHENOL [HSDB] | M-CHLOROPHENOL [MI] | 3-chloro phenol | PS-6042 | 3-Chloro-1-hydroxybenzene | m-Chlorophenol, solid | Z2Z7M2FTAD | 3CH | BDBM50167952
Specifications & Purity
analytical standard
Storage
Protected from light, Room temperature
Shipped In
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Grade
Analytical standard
Names and Identifiers
Canonical SmilesC1=CC(=CC(=C1)Cl)O
IUPAC Name3-chlorophenol
InChIKeyHORNXRXVQWOLPJ-UHFFFAOYSA-N
INCHI1S/C6H5ClO/c7-5-2-1-3-6(8)4-5/h1-4,8H
Isomeric SMILES C1=CC(=CC(=C1)Cl)O
WGK Germany 3
RTECS SK2450000
UN Number 2020
Packing Group III
Molecular Weight 128.56
Beilstein 1634401
Reaxy-Rn 1634401
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1634401&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassPhenols
SubclassHalophenols
Intermediate Tree Nodes Chlorophenols
Direct ParentM-chlorophenols
Alternative Parents Chlorobenzenes  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Aryl chlorides  Organooxygen compounds  Organochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents 3-chlorophenol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Halobenzene - Chlorobenzene - Monocyclic benzene moiety - Aryl halide - Aryl chloride - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organochloride - Organohalogen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as m-chlorophenols. These are chlorophenols carrying a iodine at the C3 position of the benzene ring.
External Descriptors a chloroaromatic compound
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALB Tchem Serum albumin (2651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H2 Tchem LXR-beta (3841 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
E Lysozyme (95 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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Lot NumberCertificate TypeDateItem
K2009551Certificate of AnalysisFeb 24, 2026 C104276
Chemical and Physical Properties
SolubilitySlightly soluble in water, soluble in alcohols, ethers, and lyes.
SensitivityLight sensitive.
Freezing Point(°C)33 °C
Refractive Index1.5565
Flash Point(°F)248.0 °F
Flash Point(°C)120℃
Boil Point(°C)214°C
Melt Point(°C)33.5°C
Molecular Weight128.550 g/mol
XLogP32.500
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass128.003 Da
Monoisotopic Mass128.003 Da
Topological Polar Surface Area20.200 Ų
Heavy Atom Count8
Formal Charge0
Complexity74.900
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang.  (2023)  Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38171066] [10.1016/j.chroma.2023.464625]
2. Shaohui Jiang, Qingsong Li, Botao Xu, Tao Zou, Yan Zhang, Wei Ping, Qiang Ma.  (2023)  Synthesis and Application of a Novel Multi-Branched Block Polyether Low-Temperature Demulsifier.  MOLECULES,  28  (24): (8109).  [PMID:38138594] [10.3390/molecules28248109]
3. Yang Yang, Bo Jiang, Yingshuang Shang, Qinfei Xu, Junjie He, Xuefeng Li, Haibo Zhang.  (2023)  The effect of 3D printing fluorene-containing poly (aryl ether ketone)/poly (ether ketone) blends on interlayer strength.  POLYMER,      [PMID:] [10.1016/j.polymer.2023.126497]
4. Xuemei Wang, Yuan Ma, Zheng Zhou, Zhen Zhang, Jie Zhang, Lin Fan, Xinzhen Du, Xiaoquan Lu.  (2023)  Ultrarapid synthesis of dumbbell-shaped carbon black-doped Ce (III, IV)-MOF composites for fabrication of simultaneous electrochemical sensor of dopamine and acetaminophen.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2023.109430]
5. Jing Zhu, Hongwei Jiang, Wenwu Wang.  (2023)  Colorimetric sensor array for discriminating and determinating phenolic pollutants basing on different ratio of ligands in Cu/MOFs.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37647664] [10.1016/j.jhazmat.2023.132418]
6. Libao Han, Minghuo Wu, Yufeng Hu.  (2023)  Colorimetric Detection of Multiple Phenols Based on Multifunctional Fe3O4/SnS2 Composites.  ChemPlusChem,  88  (7): (e202300247).  [PMID:37414731] [10.1002/cplu.202300247]
7. Muhammad Yasir Nawabi, Waqar Uddin, Gang Hu.  (2023)  Identification of the three Isomers of Monochlorophenol: Application of Briggs-Rauscher Oscillation.  International Journal of Electrochemical Science,      [PMID:] [10.20964/2022.04.54]
8. Juntao Wang, Jiajia Liu, Weihua Liu, Ziwang Liu, Qiuhua Wu, Zhi Wang, Hongyuan Yan.  (2023)  A phenyl-functionalized nitrogen-rich magnetic hyper crosslinked polymer for magnetic solid-phase extraction of 5-nitroimidazoles residues in water and fish samples.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2023.108936]
9. Sichang Jiang, Zhi Li, Xiumin Yang, Min Li, Chun Wang, Zhi Wang, Qiuhua Wu.  (2022)  Sustainable and green synthesis of porous organic polymer for solid-phase extraction of four chlorophenols in water and honey.  FOOD CHEMISTRY,      [PMID:36283305] [10.1016/j.foodchem.2022.134652]
10. Min Li, Weihua Liu, Xufeng Meng, Shuofeng Li, Qianqian Wang, Yaxing Guo, Yuanyuan Wu, Lin Hao, Xiumin Yang, Zhi Wang, Chun Wang, Qiuhua Wu.  (2022)  Facile synthesis of magnetic hypercrosslinked polymer for the magnetic solid-phase extraction of benzoylurea insecticides from honey and apple juice samples.  FOOD CHEMISTRY,      [PMID:35792491] [10.1016/j.foodchem.2022.133596]
11. Mingfeng Yang, Yuqi Zou, Xiao Wang, Xiang Liu, Chunli Wan, Marie Harder, Qun Yan, Jiangkun Nan, Ioanna Ntaikou, Georgia Antonopoulou, Gerasimos Lyberatos, Yi Zhang.  (2022)  Synthesis of intracellular polyhydroxyalkanoates (PHA) from mixed phenolic substrates in an acclimated consortium and the mechanisms of toxicity.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2022.107944]
12. Qinfei Xu, Wenhan Xu, Yang Yang, Xin Yin, Chenyi Zhou, Jinxuan Han, Xuefeng Li, Yingshuang Shang, Haibo Zhang.  (2022)  Enhanced interlayer strength in 3D printed poly (ether ether ketone) parts.  Additive Manufacturing,      [PMID:] [10.1016/j.addma.2022.102852]
13. Haotian Zhong, Yuting Xue, Bin Liu, Zhengbo Chen, Kai Li, Xia Zuo.  (2022)  Construction of a colorimetric sensor array based on the coupling reaction to identify phenols.  Analytical Methods,  14  (9): (892-899).  [PMID:35171157] [10.1039/D1AY02076E]
14. Shengnan Huang, Fan Tian, Jiawei Dai, Xuesong Tian, Guangfang Li, Yunling Liu, Zhiquan Chen, Rong Chen.  (2021)  Highly efficient degradation of chlorophenol over bismuth oxides upon near-infrared irradiation: Unraveling the effect of Bi-O-Bi-O defects cluster and 1O2 involved process.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2021.120576]
15. Weihua Liu, Juntao Wang, Shuangju Song, Lin Hao, Jiajia Liu, Yangjuan An, Yaxing Guo, Qiuhua Wu, Chun Wang, Zhi Wang.  (2021)  Facile synthesis of uniform spherical covalent organic frameworks for determination of neonicotinoid insecticides.  FOOD CHEMISTRY,      [PMID:34343809] [10.1016/j.foodchem.2021.130653]
16. Li Zhijun, Zhang Mingyang, Zhang Lili, Dong Xiuli, Leng Leipeng, Horton J. Hugh, Wang Jun.  (2021)  Engineering the atomic interface of porous ceria nanorod with single palladium atoms for hydrodehalogenation reaction.  Nano Research,  15  (2): (1338-1346).  [PMID:] [10.1007/s12274-021-3662-y]
17. Zhiyuan Feng, Qingling Tian, Qianqian Yang, Yanbo Zhou, Hongying Zhao, Guohua Zhao.  (2021)  Selectively photoelectrocatalytic reduction of oxygen to hydroxyl radical and singlet oxygen: Mechanism and validation in coal wastewater.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2021.119908]
18. Zong-Da Du, Yuan-Yuan Cui, Cheng-Xiong Yang.  (2020)  Fabrication of spherical silica amino-functionalized microporous organic network composites for high performance liquid chromatography.  TALANTA,      [PMID:33076117] [10.1016/j.talanta.2020.121570]
19. Qingling Tian, Fan Xiao, Hongying Zhao, Xianbin Fei, Xuqian Shen, Georgeta Postole, Guohua Zhao.  (2020)  Simultaneously accelerating the regeneration of FeII and the selectivity of 2e- oxygen reduction over sulfide iron-based carbon aerogel in electro-Fenton system.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2020.119039]
20. Wang Qianqian, Li Gaigai, Wang Chun, Wu Qiuhua, Wang Zhi.  (2020)  Layered porous organic frameworks as a novel adsorbent for the solid phase extraction of chlorophenols prior to their determination by HPLC-DAD.  MICROCHIMICA ACTA,  187  (4): (1-11).  [PMID:32152748] [10.1007/s00604-020-4195-x]
21. Yinhui Yang, Meiling Qi, Jinliang Wang.  (2020)  Tetraphenylethylene-functionalized hexaphenylbenzene with unique conformation-driven selectivity for gas chromatographic separations.  NEW JOURNAL OF CHEMISTRY,  44  (7): (2890-2896).  [PMID:] [10.1039/C9NJ05545B]
22. Meng Xie, Junchuan Tang, Lingshuai Kong, Wenhui Lu, Vinothkumar Natarajan, Feng Zhu, Jinhua Zhan.  (2018)  Cobalt doped g-C3N4 activation of peroxymonosulfate for monochlorophenols degradation.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2018.10.130]
23. Xiuling Xu, Fan Hu, Yuwei Ma, Jinming Gao, Qi Shuai.  (2018)  Facile microwave synthesis, structural diversity and herbicidal activity of six novel alkaline-earth metal complexes (AECs) based on skeletal isomerization chlorophenoxyacetic acids.  NEW JOURNAL OF CHEMISTRY,  42  (6): (4155-4166).  [PMID:] [10.1039/C8NJ00107C]
24. Zang Xiaohuan, Chang Qingyun, Liang Weiqian, Wu Tong, Wang Chun, Wang Zhi.  (2017)  Micro-solid phase extraction of chlorophenols using reduced graphene oxide functionalized with magnetic nanoparticles and graphitic carbon nitride as the adsorbent.  MICROCHIMICA ACTA,  185  (1): (1-9).  [PMID:29594457] [10.1007/s00604-017-2546-z]
25. Juntao Wang, Menghua Li, Caina Jiao, Yuhong Song, Chun Wang, Qiuhua Wu, Zhi Wang.  (2017)  Preparation of a magnetic porous organic polymer for the efficient extraction of phenylurea herbicides.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:28888678] [10.1016/j.chroma.2017.09.001]
26. Juanjuan Wu, Ruiyang Ma, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang.  (2017)  Triphenylamine-based hypercrosslinked organic polymer as adsorbent for the extraction of phenylurea herbicides.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:28903856] [10.1016/j.chroma.2017.09.012]
27. Li Gao, Yinmao Wei.  (2016)  Fabrication of a novel hydrophobic/ion-exchange mixed-mode adsorbent for the dispersive solid-phase extraction of chlorophenols from environmental water samples.  JOURNAL OF SEPARATION SCIENCE,  39  (16): (3186-3194).  [PMID:27420911] [10.1002/jssc.201501299]
28. Yue Zhang, Zhiyong Li, Huiyong Wang, Xiaopeng Xuan, Jianji Wang.  (2016)  Efficient separation of phenolic compounds from model oil by the formation of choline derivative-based deep eutectic solvents.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2016.03.014]
29. Xiuling Xu, Saisai Yan, Fan Hu, Wei Zhao, Qi Shuai.  (2016)  Calcium coordination compounds based on phenoxyacetic acids: microwave synthesis, thermostability and influences on the crystal structures of chlorine substituent group on ligands.  JOURNAL OF COORDINATION CHEMISTRY,      [PMID:] [10.1080/00958972.2015.1126259]
30. Xingli Liu, Xin Zhou, Chun Wang, Qiuhua Wu, Zhi Wang.  (2015)  Magnetic three-dimensional graphene solid-phase extraction of chlorophenols from honey samples.  Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment,      [PMID:25397363] [10.1080/19440049.2014.983999]
31. Chun Wang, Ruiyang Ma, Qiuhua Wu, Meng Sun, Zhi Wang.  (2014)  Magnetic porous carbon as an adsorbent for the enrichment of chlorophenols from water and peach juice samples.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25145565] [10.1016/j.chroma.2014.08.002]
32. Xiao Wei, Zhiping Zhou, Jiangdong Dai, Tongfan Hao, Hongji Li, Yeqing Xu, Lin Gao, Jianming Pan, Chunxiang Li, Yongsheng Yan.  (2014)  Composites of surface imprinting polymer capped Mn-doped ZnS quantum dots for room-temperature phosphorescence probing of 2,4,5-trichlorophenol.  JOURNAL OF LUMINESCENCE,      [PMID:] [10.1016/j.jlumin.2014.07.001]
33. Mei Zhang, Jun-Hui Zhang, Yan Zhang, Bang-Jin Wang, Sheng-Ming Xie, Li-Ming Yuan.  (2013)  Chromatographic study on the high performance separation ability of a homochiral [Cu2(d-Cam)2(4,4′-bpy)]n based-column by using racemates and positional isomers as test probes.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:24373537] [10.1016/j.chroma.2013.12.023]
34. Jinyu Chu, Bing Wang, Yujun Song, Xiaohua Zou, Chunxiang Li, Yongsheng Yan.  (2012)  Selective Removal of 2,4-Dichlorophenol by Surface Molecularly Imprinted Polymers Based on Amino-Functionalized Fe3O4@SiO2 Composites.  ADSORPTION SCIENCE & TECHNOLOGY,      [PMID:] [10.1260/0263-6174.30.5.409]
35. Zheng Li, Jiehao Xie, Zipin Peng, Zhuo Ma, Yihui Li, Xingkun Chen, Yuan Tan, Wenshao Yang, Yunjie Ding.  (2024)  Enhanced catalytic performance induced by synergistic interaction between Pd species with NiAl2O4 spinel support for aqueous-phase hydrodechlorination of 4-chlorophenols.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.154399]
36. Zhiwei Zhao, Yu Li, Fei Wang, Zhitao Xu, Sai Zhang, Li Li, Junyu Fan, Jie Liu.  (2024)  Generation of dichloroacetonitrile with the co-presence of g-C3N4 and chloride in peroxymonosulfate/Vis system: Impacts and mechanism.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.149541]
37. Xiaowen Jiang, Junteng Zhao, Tong Yu, Yijun Li, Xiwen He, Langxing Chen, Yukui Zhang.  (2025)  Growth of quinoline-linked covalent organic frameworks on electrospun nanofibers with enhanced adsorption on chlorinated phenols.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.159518]
38. Yanqing Cong, Yudi Wang, Dongchen Lv, Jiayi Gao, Kuangda Chen, Sainan Sun, Xiaoran Wang, Shi-Wen Lv.  (2024)  Introduction of Lewis acid sites to endow cobalt phosphide with peroxidase-like and oxidase-like activities and application in colorimetric sensing analysis.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.136790]
39. Yifan Shao, Sainan Sun, Xinyun Li, Liwen Fan, Xinyi Shen, Yanqing Cong, Shi-Wen Lv.  (2024)  Spatial confinement of Mn3O4 in hollow carbon sphere to boost the oxidase-like activity for colorimetric sensing analysis of hydroquinone and hexavalent chromium.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.112415]
40. Yang Zheng, Tongkui Yue, Guanghui Cui, Yi Sun, Wei Liu, Jun Liu, Zhanpeng Wu.  (2025)  Synthesis of Chlorinated Polyphosphazenes with Improved Interfacial Strength for Novel Flexible Heat Shielding Materials.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.5c00137]
41. Liang Zeng, Sizhe Yang, Quan Chen, Wang Fu, Min Wu, Patryk Oleszczuk, Bo Pan, Baoshan Xing.  (2024)  The critical role of electron donating rate of pyrogenic carbon in mediating the degradation of phenols in the aquatic environment.  WATER RESEARCH,      [PMID:39128335] [10.1016/j.watres.2024.122217]
42. Jianqiao Liu, Jinli Wang, Jiang Guo, Kai Yan, Jingdong Zhang.  (2025)  Solar-powered enzymatic-photoelectrocatalytic system constructed with three-dimensional dual photoelectrodes for highly efficient purification of coking wastewater.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40319512] [10.1016/j.jcis.2025.137761]
43. Zihan Xu, Ziyi Guo, Shengran Yu, Xinyi Shen, Yanqing Cong, Tong Wei, Wenming Pei, Shi-Wen Lv.  (2026)  Modulation of cobalt spin state to enhance enzyme-like activity of cobaltous oxide for colorimetric sensing analysis of phenolic compound.  FOOD CHEMISTRY,      [PMID:41762878] [10.1016/j.foodchem.2026.148654]
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