3-IN-PP1 , CAS No.2227110-54-3

CAS: 2227110-54-3 Cat. No.: I646561 Summenformel: C₁₇H₁₈N₆ Molekulargewicht: 306.37

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Übersicht

3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1 , PKD2 and PKD3 with IC 50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer

In Vitro

3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC 50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 (5 μM, 0-114 h) displays potent anti-proliferative activity against PANC-1 cells. 3-IN-PP1 (20 μM, 1 h) potently blocks PKD-dependent cortactin phosphorylation in PANC-1 cells. 3-IN-PP1 has inhibition of different tumor cell growth with IC 50 values range from 1.6 to 39.2μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: PANC-1 cell Concentration: 5 μM Incubation Time: 0-114 h Result: Significantly inhibited PANC-1 cell proliferation after incubation for 96 and 144 hours. Western Blot AnalysisCell Line: PANC-1 cells Concentration: 20 μM Incubation Time: 1 h Result: Reduced cortactin phosphorylation in PANC-1 cells.

Form:Solid

IC50& Target:PKD1 108 nM (IC 50 ) Cellular PKD2 94 nM (IC 50 ) PKD3 108 nM (IC 50 )

Specifications

Biochemische und physiologische Mechanismen

3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1 , PKD2 and PKD3 with IC 50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of severa

Storage

Store at 2-8°C,Protected from light,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Molekulargewicht: 306.37

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 100 mg/mL (326.40 mM; Need ultrasonic)

Häufig gestellte Fragen

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2227110-54-3, the molecular formula is C17H18N6, and the molecular weight is 306.37 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.