8-Azaadenosin - ≥98%(HPLC) , CAS No.10299-44-2

CAS: 10299-44-2 Cat. No.: A288533 Summenformel: C₉H₁₂N₆O₄ Molekulargewicht: 268.23

GRADE & PURITY ≥98%(HPLC)

Synonyms

(2R,3R,4S,5R)-2-{7-amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}-5-(hydroxymethyl)oxolane-3,4-diol | 3-?-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine | 8-Azaadenosine | 8-Aza-adenosine | Q27105620 | HY-115686 | 3-beta-D-Ribofuranosyl-3H-1,2,

Storage

Lagerung bei -20°C, Argon geladen

Shipped In

Eistruhe + Eispads

Specifications

Synonyme

(2R,3R,4S,5R)-2-{7-amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}-5-(hydroxymethyl)oxolane-3,4-diol | 3-?-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine | 8-Azaadenosine | 8-Aza-adenosine | Q27105620 | HY-115686 | 3-beta-D-Ribofuranosyl-3H-1,2,

Spezifikationen & Reinheit

≥98%(HPLC)

Biochemische und physiologische Mechanismen

ADAR1-Hemmer (Adenosin-Deaminasen, die auf doppelsträngige RNA wirken). Verringert die A-zu-I-Editieraktivität in einer Leukämie-Zelllinie, stellt die Let-7 wieder her und hemmt die Selbsterneuerung von Leukämie-Stammzellen in vitro.

Storage

Lagerung bei -20°C, Argon geladen

Verschickt in

Eistruhe + Eispads

Aktionsart

INHIBITOR

Reinheit

≥98%(HPLC)

Namen und Kennungen

Pubchem Sid

528762868

Kanonisches Lächeln

C1=NC(=C2C(=N1)N(N=N2)C3C(C(C(O3)CO)O)O)N

IUPAC Name

(2R,3R,4S,5R)-2-(7-aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol

InChIKey

OAUKGFJQZRGECT-UUOKFMHZSA-N

INCHI

1S/C9H12N6O4/c10-7-4-8(12-2-11-7)15(14-13-4)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H2,10,11,12)/t3-,5-,6-,9-/m1/s1

Isomere SMILES

C1=NC(=C2C(=N1)N(N=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N

Molekulargewicht

268.23

Reaxy-Rn

1226020

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1226020&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Klasse Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Ebene5 Glycosyl compounds
          • Ebene6 Glycosylamines

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Klasse: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: Glycosylamines
• Alternative Parents: Pentoses Triazolopyrimidines Aminopyrimidines and derivatives Imidolactams Triazoles Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Azacyclic compounds Primary amines Primary alcohols Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-glycosyl compound - Pentose monosaccharide - Triazolopyrimidine - Aminopyrimidine - Monosaccharide - Pyrimidine - Imidolactam - Azole - Heteroaromatic compound - 1,2,3-triazole - Triazole - Tetrahydrofuran - Secondary alcohol - Organoheterocyclic compound - Azacycle - Oxacycle - Primary amine - Primary alcohol - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Amine - Alcohol - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as glycosylamines. These are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether).
• External Descriptors: N-glycosyl compound

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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ADA Tclin Adenosine deaminase (129 Activities)

Discover Target: ADA

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Bos taurus (956 Activities)

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L1210 (27553 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 26.82, Max Conc. mM: 100
• Empfindlichkeit: Moisture sensitive
• Molekulargewicht: 268.230 g/mol
• XLogP3: -2.200
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 268.092 Da
• Monoisotopic Mass: 268.092 Da
• Topological Polar Surface Area: 152.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 336.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1