9-Phenanthrol - Moligand™, 10mM in DMSO , Channel blocker of TRPM4, CAS No.484-17-3, Channel blocker of TRPM4

CAS: 484-17-3 Cat. No.: P424202 Summenformel: C₁₄H₁₀O Molekulargewicht: 194.23 EG-Nummer: 207-602-4 PubChem CID: 10229

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Synonyms

HY-108457 | NSC50554 | NSC-50554 | UNII-9FYU45OV9H | DTXCID7027592 | DZKIUEHLEXLYKM-UHFFFAOYSA- | 4-06-00-04937 (Beilstein Handbook Reference) | Tox21_300618 | BRN 2047057 | GTPL4114 | SY113803 | Phenanthren-9-ol | SCHEMBL508755 | BDBM50526033 | CCRIS 184

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Spezifikationen

Synonyme

HY-108457 | NSC50554 | NSC-50554 | UNII-9FYU45OV9H | DTXCID7027592 | DZKIUEHLEXLYKM-UHFFFAOYSA- | 4-06-00-04937 (Beilstein Handbook Reference) | Tox21_300618 | BRN 2047057 | GTPL4114 | SY113803 | Phenanthren-9-ol | SCHEMBL508755 | BDBM50526033 | CCRIS 184

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Selective TRPM4 blocker (IC 50 = 20 μM). Modulates smooth muscle contraction. Reduces LPS-induced cell death. Promotes angiogenesis. Shows cardioprotective and anti-ischemic effects in vivo.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

CHANNEL BLOCKER

Mechanismus der Wirkung

Channel blocker of TRPM4

Namen und Kennungen

Pubchem Sid

528762960

Kanonisches Lächeln

C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O

IUPAC Name

phenanthren-9-ol

InChIKey

DZKIUEHLEXLYKM-UHFFFAOYSA-N

INCHI

1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H

Isomere SMILES

C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O

WGK Deutschland

3

RTECS

SF8288000

PubChem CID

10229

Molekulargewicht

194.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Phenanthrenes and derivatives
      • Subclass Phenanthrols

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Phenanthrenes and derivatives
• Subclass: Phenanthrols
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenanthrols
• Alternative Parents: Naphthols and derivatives 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Phenanthrol - 1-naphthol - 2-naphthol - Naphthalene - 1-hydroxy-2-unsubstituted benzenoid - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as phenanthrols. These are compounds containing a phenanthrene (or its hydrogenated derivative) to which a hydroxyl group is attached.
• External Descriptors: phenanthrol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

TRPM4 Tchem Transient receptor potential cation channel subfamily M member 4 (0 Activities)

Discover Target: TRPM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HL-60 (67320 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 194.230 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 194.073 Da
• Monoisotopic Mass: 194.073 Da
• Topological Polar Surface Area: 20.200 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 225.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1