A 71915 TFA, Antagonist of Guanylyl cyclase-A, CAS No.132956-87-7, Antagonist of Guanylyl cyclase-A

CAS: 132956-87-7 Cat. No.: A288395 Molecular Weight: 1613.95(free) PubChem CID: 25083020

GRADE & PURITY Moligand™, ≥98%

Specifications

Product Name

A 71915 TFA, Antagonist of Guanylyl cyclase-A, CAS No.132956-87-7

Synonyms

(Arginyl(6)-cyclohexylalanyl(8))anp-(6-15)-D-1, 2, 3, 4-tetrahydro-3-isoquinolinecarbonyl-arginyl-cysteinamide | L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-D-1, 2, 3, 4-te

Grade

Moligand™

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi= 9.18). Reduces brain natriuretic peptide (BNP)-induced scratching in mice.

Sequence

RCXGGRIDRIXRC(Modifications: X-3 = Cha, X-11= D-Tic, Cys-13 = C-terminal amide, Disulfide bridge between Cys-2 - Cys-13)

Action Type

ANTAGONIST

Mechanism of action

Antagonist of Guanylyl cyclase-A

CAS

132956-87-7

Molecule Type

Small molecule

Storage and Shipping

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Associated Targets(Human)

NPR1 Tclin Atrial natriuretic peptide receptor 1 (0 Activities)

Discover Target: NPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Genetic information

• Alternate Names: (Arginyl(6)-cyclohexylalanyl(8))anp-(6-15)-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-arginyl-cysteinamide | L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-D-1,2,3,4-te
• Reference:
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