QUALITÄT & REINHEITMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Synonyms
A83-01|A-83-01|4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidine|(trans-3-aminocyclobutyl)methanol|Stemolecule A83-01|1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-|3-(6-Methyl-2-pyridinyl)-N-phenyl-4 -(4-quinolinyl)-1H-pyrazole-1-carbothioamide|ALK5 Inhibitor IV|TGF-beta inhibitor A-83-01|(2S,4R)-1-t-butoxycarbonyl-4-methylsulfonyloxy-2-methoxycarbonylpyrrolidine|A 83-01 is known as an ALK5, ALK4, and ALK7 inhibitor.|A 83-01 (GMP)|3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide|A 83-01|1H-Pyrazole-1-carbothioamide,3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-|3-(6-Methyl-2-pyridyl)-N-phenyl-4-(4-quinolinyl)pyrazole-1-carbothioamide|3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-yl-1H-pyrazole-1-carbothioamide|3-(6-methyl-2-pyridinyl)-n-phenyl-4-(4-quinolinyl)-1h-pyrazole-1-carbothioamide
Storage
Protected from light,Store at -20°C,Argon charged,Desiccated
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively。
Spezifikationen
Synonyme
A83-01 | A-83-01 | 4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidine | (trans-3-aminocyclobutyl)methanol | Stemolecule A83-01 | 1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)- | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4 -(4-quinolinyl)-1H-pyrazole-1-carbothioamide | ALK5 Inhibitor IV | TGF-beta inhibitor A-83-01 | (2S,4 Show more
Spezifikationen & Reinheit
Moligand™, ≥98%
Biochemische und physiologische Mechanismen
Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC 50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). Active in vivo and in vitro . A 83-01 is a TGFβ kin
Quelle
Synthetic
Storage
Protected from light,Store at -20°C,Argon charged,Desiccated
Verschickt in
Ice chest + Ice pads
Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.
Note
Moligand™
Hinweis
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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