Aβ/tau aggregation-IN-1 - 10mM in DMSO , CAS No.2252162-81-3

CAS: 2252162-81-3 Cat. No.: A654458 Summenformel: C₂₅H₂₁IN₂O Molekulargewicht: 492.35

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier

In Vitro

Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci. Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ 1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ 1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ 1-42 and tau. The K D value of Aβ/tau aggregation-IN-1 with Aβ 1-42 is 160 μM. The K D value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ 1-42 and tau through noncovalent interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: HEK-293 T cells Concentration: 1 μM Incubation Time: 24 hours Result: Significantly declined the tau aggregation foci.

IC50& Target:Kd: 160 μM (Aβ1-42),Kd: 337 μM (tau)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier

Storage

Protected from light,Desiccated,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Molekulargewicht: 492.35