ABBV-744 - Moligand™, 10mM in DMSO , CAS No.2138861-99-9

CAS: 2138861-99-9 Cat. No.: A409120 Summenformel: C₂₈H₃₀FN₃O₄ Molekulargewicht: 491.55

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Synonyms

1H-​Pyrrolo[2,​3-​c]​pyridine-​2-​carboxamide, N-​ethyl-​4-​[2-​(4-​fluoro-​2,​6-​dimethylphenoxy)​-​5-​(1-​hydroxy-​1-​methylethyl)​phenyl]​-​6,​7-​dihydro-​6-​methyl-​7-​oxo-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

ABBV-744 ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.
In vitro

ABBV-744 is a potent inhibitor specific for BDII of BRD2/3/4, with >250-fold differential binding preference for BDII over BDI and excellent drug-like properties. ABBV-744 is also a potent and selective inhibitor of the AR (androgen receptor) transcription pathway.

In vivo

In vivo, doses of ABBV-744 at fractions of its maximum tolerated dose (MTD) induces tumor growth inhibition in AML and prostate cancer xenograft models that were comparable to those observed with ABBV-075 when dosed at its MTD.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spezifikationen

Synonyme

1H-​Pyrrolo[2,​3-​c]​pyridine-​2-​carboxamide, N-​ethyl-​4-​[2-​(4-​fluoro-​2,​6-​dimethylphenoxy)​-​5-​(1-​hydroxy-​1-​methylethyl)​phenyl]​-​6,​7-​dihydro-​6-​methyl-​7-​oxo-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Produkteigenschaften

ALogP

4.36

hba_count

3

HBD-Zahl

2

Rotationsfähige Bindung

6

Namen und Kennungen

Isomere SMILES

CCNC(=O)C1=CC2=C(N1)C(=O)N(C=C2C3=C(C=CC(=C3)C(C)(C)O)OC4=C(C=C(C=C4C)F)C)C

Molekulargewicht

491.55

Reaxy-Rn

31981858

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31981858&ln=

Zugehörige Ziele (menschlich)

BRD4 Tchem Bromodomain-containing protein 4 (5 Activities)

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRDT Tchem Bromodomain testis-specific protein (2 Activities)

Discover Target: BRDT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD3 Tchem Bromodomain-containing protein 3 (1 Activities)

Discover Target: BRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD2 Tchem Bromodomain-containing protein 2 (1 Activities)

Discover Target: BRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 98
• DMSO (mM) Maximale Löslichkeit: 199.369341877734
• Wasser (mg/ml) Maximale Löslichkeit: ＜1

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2138861-99-9, the molecular formula is C28H30FN3O4, and the molecular weight is 491.55 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.