Abi-DZ-1 , CAS No.A1450959

CAS: A1450959 Cat. No.: A1450959 Summenformel: C₆₃H₇₆ClN₃O₅S Molekulargewicht: 1022.81

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Abi-DZ-1 is a potential multifunctional theranostic agent via the HIF1α/OATPs Pathway. Abi-DZ-1 can be used in the research of tumor-targeted imaging and precision therapy.

Specifications

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Molekulargewicht

1022.81

Application Protocols

Validated application protocols are not supplied for this item.

• Tested applications (e.g., WB, IHC, IF, FC, enzymatic assays): Not specified for this item; refer to CoA/Spec Sheet.
• Recommended concentrations/dilutions: Not specified for this item; refer to CoA/Spec Sheet.
• Positive controls/standards: Not specified for this item; refer to CoA/Spec Sheet.

General protocol guidance (non-item-specific)

• Stock preparation: If soluble, prepare a concentrated stock (e.g., 10–50 mM in DMSO or appropriate buffer), filter if required, and aliquot to single-use vials to avoid freeze–thaw.
• Assay setup: Establish a pilot range-finder to determine non-toxic and efficacious concentration windows; include vehicle controls.
• Documentation: Record lot numbers and storage history; verify identity/purity prior to pivotal experiments.

Contact Aladdin Scientific support for any available internal protocols or user-contributed methods.

Biological Roles

No biological function or target information is provided for Abi-DZ-1 in the current listing.

• Intended use: For research use only (not for human or veterinary use).
• Biological activity/target class: Not specified for this item; refer to CoA/Spec Sheet or supplier dossier.

General guidance (non-item-specific)

• If used as a tool compound, ensure specificity by orthogonal assays (e.g., biochemical vs cell-based), and include inactive analogs or competitive controls where available.
• If nucleic-acid or peptide based, confirm sequence, modification pattern, and counter-ions; assess nuclease/protease stability as appropriate.
• For cell work, determine working concentration ranges via preliminary dose–response and monitor for nonspecific cytotoxicity using standard viability assays.

Documentation

• Cite lot-specific CoA for any reported bioactivity, KD/IC50, or binding data. In absence of such data, treat as an uncharacterized research reagent.

Buffer Applications

Item-specific buffer preferences for Abi-DZ-1 are not available.

General guidance (not item-specific)

• If water-soluble: Start with PBS (pH 7.2–7.4) or HEPES (pH 7.2–7.6) for cell-based assays; adjust ionic strength to minimize nonspecific interactions.
• If poorly soluble in water: Prepare a concentrated DMSO stock and dilute into buffer ensuring final DMSO ≤0.5–1% v/v; consider adding 0.01–0.1% nonionic surfactant (e.g., Tween-20) if compatible.
• For pH-sensitive materials: Use Good’s buffers (HEPES, MOPS, MES) within their effective pKa ±1 range; avoid phosphate if metal-coordination or precipitation is a concern.
• Filtration: 0.22 μm sterile filtration if solutions are intended for cell culture.

Not provided for this item

• Recommended buffer composition, pH range, stabilizers, and compatible excipients: Not specified for this item; refer to CoA/Spec Sheet.

Green Alternatives

Without structural details for Abi-DZ-1, selection of greener media focuses on general solvent and process choices that reduce hazard and environmental footprint.

General strategies (not item-specific)

• Prefer water or aqueous buffers when chemically compatible.
• For organic media, consider biorenewable or lower-toxicity options (e.g., ethanol, 2-MeTHF, CPME, EtOAc, propylene carbonate) over chlorinated or highly toxic solvents.
• Minimize DMSO percentage in biological assays to reduce cytotoxicity and downstream waste load; consider aqueous cosolvent systems.
• Implement microscale workflows and high-throughput screening to reduce solvent consumption.

Illustrative comparison (general; not specific to Abi-DZ-1)

• DCM/CHCl3 vs EtOAc/2-MeTHF: EtOAc/2-MeTHF often provide comparable solvency with improved safety/greenness.
• DMF/NMP vs Cyrene/propylene carbonate: Emerging bio-based dipolar aprotics may substitute in some reactions or extractions.

Operational improvements

• Closed-system handling to reduce VOC emissions.
• Solvent recycling where feasible.

Note

• Verify chemical compatibility and stability of Abi-DZ-1 in any alternative solvent before scale-up. Item-specific green metrics are not available.

Pharmaceutical Uses

This product is supplied strictly for research use only and is not intended for use in human or veterinary applications, diagnostics, or as an API/excipient.

• Pharmacopeial status: Not specified for this item; refer to CoA/Spec Sheet.
• GMP/clinical suitability: Not applicable; no claims are made for clinical or manufacturing use.

General formulation context (non-item-specific)

• If method development is required (e.g., analytical characterization), typical reference matrices include simulated gastric/intestinal fluids, simple buffers, or placebo blends; these are for in vitro research only.
• For preformulation-style studies, solubility profiling across pH 2–9 and cosolvent systems can inform assay design; ensure all outputs remain within research scope and institutional policies.

Note

• No therapeutic, diagnostic, or clinical claims are made or should be inferred for Abi-DZ-1.

Physical Properties

Item-specific physicochemical properties are not provided in the current listing.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point / Freezing point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility profile (water/organic): Not specified for this item; refer to CoA/Spec Sheet.
• LogP/logD, pKa: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index, optical rotation (if applicable): Not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/practice, not item-specific)

• If composition is unknown, run a mini solubility screen across orthogonal solvents/buffers (e.g., water, PBS, MeOH, DMSO, acetonitrile, 2-MeTHF) at small scale (1–2 mg in 0.5 mL) and evaluate by visual inspection and HPLC/UPLC.
• For hygroscopic or labile materials, weigh quickly in a low-humidity environment and store at the recommended temperature immediately after aliquoting.
• If the reagent is peptide-/oligo-like, typical good solvents include water, PBS, or aqueous buffers with 10–20% acetonitrile; for small hydrophobic molecules, DMSO stock solutions (10–50 mM) are common.

Quality and Grades

Item-specific grade/purity is not listed.

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

General notes on grades (for context; not item-specific)

• Research Grade: Suitable for general laboratory use; may not be certified for trace contaminants.
• Analytical/AR Grade: Tight specifications for assay and common impurities; intended for analytical workflows.
• HPLC/LC–MS Grade (solvents/reagents): Low UV absorbance and low nonvolatile residues; optimized for chromatographic detection.
• Bio/Cell Culture Grade: Additional controls for endotoxin, bioburden, and sometimes mycoplasma; may be sterile/filtered.

Quality controls to request when relevant

• Identity confirmation: NMR/HRMS/LC–MS, peptide mapping (if biopolymer), or sequencing data.
• Purity profile: HPLC/UPLC area%; for oligos/peptides, crudes vs. purified (e.g., desalted, >90–98%).
• Residual solvents, water (KF), metal content, and stabilizer presence: Not specified for this item; refer to CoA/Spec Sheet.

Implications for use

• For sensitive biological assays, ask for bioburden/endotoxin data and sterility status.
• For quantitative analytical work, request chromatographic purity and any stabilizers or counter-ions that may affect detection.

Reaction and Applications

No item-specific application notes are supplied for Abi-DZ-1.

General considerations (research reagent context)

• If Abi-DZ-1 is a small molecule tool compound: Typical applications include target engagement assays, probe development, binding studies, or as a synthetic intermediate. Validate identity/purity by LC–MS/NMR before critical experiments.
• If it is a biopolymer (peptide/oligo): Common uses include binding assays, pull-downs, functional screening, or hybridization; confirm sequence and modification status via supplied documentation.

Practical tips (non-item-specific)

• Conduct a stability pre-check: incubate a test solution at room temperature and 37°C (aqueous and/or DMSO) and analyze by LC–MS over 24–48 h to set handling limits.
• For automated screening, prepare single-use aliquots to minimize freeze–thaw.
• If using in enzymatic or cell-based assays, verify that any solvent (e.g., DMSO) and excipients remain below assay interference thresholds.

Documentation

• Manufacturer Applications: Not specified for this item; refer to CoA/Spec Sheet. Expand experimental scope only after confirming supplier recommendations.

Reaction Conditions

No reaction condition data are provided for Abi-DZ-1.

General guidance (non-item-specific)

• For small molecules: Typical coupling conditions include carbodiimide or HATU-mediated amidations (DMF/MeCN, 0–25°C), Suzuki couplings (Pd catalysts, aqueous/organic biphasic or polar aprotic solvents, 25–80°C), and nucleophilic substitutions (polar aprotic, 0–60°C). Verify functional groups before selection.
• For bioconjugations: NHS-ester/amine reactions at pH 7.5–8.5, maleimide/thiol at pH 6.5–7.5, CuAAC click with CuSO4/sodium ascorbate/ligand in water/t-BuOH or PBS, typically at room temperature.
• Stability controls: Monitor by LC–MS; include time-course sampling and evaluate mass balance and impurity profile.

Expected yields and times

• Highly dependent on structure; not specified for this item. Perform small-scale scouting prior to scale-up.

Note

• Always confirm compatibility of solvent, temperature, and pH with the material once structural information is available.

Safety and Handling

Safety classification for this specific item is not provided.

• GHS Classification: Not specified for this item; refer to SDS.
• Signal Word: Not specified for this item; refer to SDS.
• Hazard (H) Statements: Not specified for this item; refer to SDS.
• Pictograms: Not specified for this item; refer to SDS.

General laboratory precautions (non-item-specific)

• Use in a fume hood or well-ventilated area. Wear appropriate PPE: lab coat, safety glasses, and chemically resistant gloves (e.g., nitrile). Avoid inhalation of dusts/aerosols and direct skin contact.
• Unknown reactivity: Keep away from strong oxidizers, strong acids/bases, and ignition sources until compatibility is known.
• First aid overview: In case of skin/eye contact, rinse with water for 15 minutes and seek medical attention. If inhaled, move to fresh air. If ingested, rinse mouth; do not induce vomiting; seek medical attention. Always follow institutional SOPs.
• Spill handling: Absorb with inert material, collect for disposal. Prevent release to drains if properties are unknown.

Authoritative source

• Always consult the product’s Safety Data Sheet (SDS) for definitive hazard information, exposure limits, and disposal guidance. For uncharacterized hazards, adopt conservative handling practices.

Solvent Selection

Solubility details for Abi-DZ-1 are not provided; choose solvents empirically based on small-scale screening.

Practical workflow (general guidance)

• Start with orthogonal classes: water/PBS (polar protic), methanol/ethanol (polar protic organic), acetonitrile/DMF/DMSO (polar aprotic), 2-MeTHF/EtOAc (moderately polar), and toluene/hexanes (nonpolar).
• Prepare 10–50 mM stock in the first solvent that achieves full clarity without precipitation for 30 minutes at room temperature. For biological assays, DMSO stocks diluted into buffer are common; keep final DMSO ≤0.5–1% v/v when possible.
• If amphoteric/ionizable, adjust pH in aqueous buffers (pH 4–9) to aid dissolution; avoid extreme pH unless stability is verified.

Notes

• Filter sterilization (0.22 μm) may be required for cell-based work if the reagent is solution-stable.
• Avoid reactive solvent systems (e.g., strong acids/bases) until chemical compatibility is known.

Comparison (general)

• DMSO: Broad solvency, excellent for hydrophobic small molecules; potential cytotoxicity at higher %.
• Water/PBS: Preferred for biocompatibility; limited for hydrophobes.
• Acetonitrile/MeOH: LC-friendly; volatility aids removal.
• 2-MeTHF/EtOAc: Greener alternatives to chlorinated solvents for extractions and processing.

Storage and Reconstitution

Item-specific storage information is provided; reconstitution details are not.

• Storage Conditions: Store at −20°C (per product data). Protect from moisture and light until stability is confirmed. Minimize freeze–thaw by aliquoting upon first opening.
• Shipped In: Ice chest + ice pads (per product data).
• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Reconstitution solvent and concentration: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (non-item-specific)

• Upon receipt: Allow the external package to equilibrate to room temperature to minimize condensation, then transfer immediately to −20°C storage.
• Aliquoting: If solid, subdivide quickly in a low-humidity environment. If solution, prepare single-use aliquots and avoid repeated freeze–thaw; consider storing at −80°C for long-term if solution-stable.
• Stability checks: After reconstitution, assess stability at intended storage temperature by periodic LC–MS/HPLC.
• Labeling: Record solvent, concentration, pH (if aqueous), date prepared, and lot number.

For definitive guidance on shelf life, compatible solvents, and solution stability, consult the lot-specific CoA/Spec Sheet.

Structure and Identity

This product is listed as Abi-DZ-1 under the Life Sciences category. Structural identifiers are not provided in the current product data.

• SKU: A1450959
• Product Name: Abi-DZ-1
• Category: Life Sciences (research reagent)
• CAS: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChI / InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural description

• No ring systems, functional groups, or stereochemical information are available for this item in the current listing.
• If you require structural confirmation (e.g., for analytical method development), please request the latest CoA/Spec Sheet or supporting dossier.

Notes

• This appears to be a proprietary or catalog-specific designation (Abi-DZ-1). Where structure-sensitive workflows are planned (e.g., LC–MS quantitation, derivatization chemistry), obtain identity data prior to use.

Synthetic Utility

Structural and functional group information for Abi-DZ-1 is not provided; therefore, specific synthetic transformations cannot be outlined.

General concepts (not item-specific)

• If Abi-DZ-1 is a small molecule intermediate, typical roles might include: coupling partner in amide/ester formation, nucleophile/electrophile in substitution/addition, or handle for further diversification (e.g., cross-coupling if halogenated). Confirm functional groups before planning routes.
• If it is a biopolymer (peptide/oligo), synthetic utility would relate to conjugation chemistry (e.g., NHS ester/thiol-maleimide click, azide–alkyne CuAAC) for probe or payload attachment.

Analytical and preparative recommendations

• Perform functional group assays (e.g., ninhydrin for primary amines, Ellman’s for thiols) where appropriate.
• Establish LC–MS methods in at least two orthogonal mobile phase systems to detect degradation or adducts.

Limitations

• Without item-specific data, treat Abi-DZ-1 as structure-unknown; avoid reactions that generate hazardous byproducts until compatibility is verified.

Target Specificity

Target, epitope, or binding specificity for Abi-DZ-1 is not provided in the current product data.

• Antigen/Target name: Not specified for this item; refer to CoA/Spec Sheet.
• Species reactivity, clone/isotype (if antibody), or modality: Not specified for this item; refer to CoA/Spec Sheet.

Guidance

• If Abi-DZ-1 is used as a biochemical probe, demonstrate specificity via orthogonal assays and appropriate negative/positive controls.
• For any binding studies, include competition experiments and off-target profiling where feasible.

Please request detailed technical documentation if target-specific use is critical for your study.