AC1-IN-1 - 10mM in DMSO , CAS No.2762422-55-7

CAS: 2762422-55-7 Cat. No.: A654655 Summenformel: C₁₈H₁₈FN₅O₂ Molekulargewicht: 355.37

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC 50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity

In Vitro

AC1-IN-1 (compound 38; HEK293 cells; 30 µM, 1 hours) shows nontoxic to this human cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: HEK293 cells Concentration: 30 µM Incubation Time: 1 hours Result: Showed nontoxic to HEK293 cells.

In Vivo

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model) Dosage: 5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline) Administration: Intravenous injection; 2 hours Result: Displayed modest, yet statistically significant, antiallodynic effects.

IC50& Target:IC 50 : 0.54 µM (AC1)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC 50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Molekulargewicht: 355.37

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2762422-55-7, the molecular formula is C18H18FN5O2, and the molecular weight is 355.37 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.