Adenosine, periodate oxidized - ≥95% , CAS No.34240-05-6

CAS: 34240-05-6 Cat. No.: A342145 Summenformel: C₁₀H₁₁N₅O₄ Molekulargewicht: 265.23

GRADE & PURITY ≥95%

Synonyms

Adenosine dialdehyde | alpha-(Hydroxymethyl)-alpha'-(6-aminopurin-9-yl)diglycolaldehyde | ADOX | s8608 | HY-123055 | CCG-267096 | 2-[1-(6-Amino-9H-purin-9-yl)-2-oxoethoxy]-3-hydroxypropanal | Adenox | 6-Amino-alpha-(1-formyl-2-hydroxyethoxy)-9H-purine-9-a

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

Adenosine, periodate oxidized is an inhibitor of S-adenosylhomocysteine hydrolase (AdoHcy hydrolase ) and it may be used in studies on the role of AdoHcy hydrolase in adenosine induce apoptosis and related S-adenosylhomocysteine-regulated processes. It is a methylation inhibitor that inhibits histone methytransferases (HMTase) and arginine methylation.

Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM)[1]. Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.  

Specifications

Synonyme

Adenosine dialdehyde | alpha-(Hydroxymethyl)-alpha'-(6-aminopurin-9-yl)diglycolaldehyde | ADOX | s8608 | HY-123055 | CCG-267096 | 2-[1-(6-Amino-9H-purin-9-yl)-2-oxoethoxy]-3-hydroxypropanal | Adenox | 6-Amino-alpha-(1-formyl-2-hydroxyethoxy)-9H-purine-9-a

Spezifikationen & Reinheit

≥95%

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥95%

Namen und Kennungen

Pubchem Sid

504756454

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504756454

Kanonisches Lächeln

C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N

IUPAC Name

2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal

InChIKey

ILMNSCQOSGKTNZ-UHFFFAOYSA-N

INCHI

1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)

Isomere SMILES

C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N

WGK Deutschland

3

Molekulargewicht

265.23

Reaxy-Rn

316940

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=316940&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Imidazopyrimidines
      • Subclass Purines and purine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Imidazopyrimidines
• Subclass: Purines and purine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: 6-aminopurines
• Alternative Parents: Aminopyrimidines and derivatives N-substituted imidazoles Monosaccharides Imidolactams Heteroaromatic compounds Azacyclic compounds Primary amines Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives Aldehydes
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 6-aminopurine - Aminopyrimidine - Monosaccharide - N-substituted imidazole - Pyrimidine - Imidolactam - Azole - Imidazole - Heteroaromatic compound - Azacycle - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Alcohol - Carbonyl group - Organic nitrogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Aldehyde - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

AHCY Tchem Adenosylhomocysteinase (1 Activities)

Discover Target: AHCY

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Zugehörige Ziele (nicht menschlich)

Ahcy Adenosylhomocysteinase (45 Activities)

Discover Target: Ahcy

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in 0.2 M HCl (50 mg/ml).
• Empfindlichkeit: Air sensitive
• Molekulargewicht: 265.230 g/mol
• XLogP3: -1.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 265.081 Da
• Monoisotopic Mass: 265.081 Da
• Topological Polar Surface Area: 133.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 331.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1