10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
AGN 192836 is a potent and selective α2 adrenergic agonist with EC 50 s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
In Vitro
Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:α adrenergic receptor
| Isomeric SMILES | CC1=C(C=CC2=C1OCCO2)NC3=NC=CN3 |
|---|---|
| PubChem CID | 10176999 |
| Molecular Weight | 231.25 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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