Aladdin™ BS(PEG)5 , CAS No.A638726

CAS: A638726 Cat. No.: A638726 Molecular Weight: 532.5

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Product introduction：

BS(PEG)5 is a bis-succinimide ester-activated PEG compound used for crosslinking between primary amines (—NH2) in proteins and other molecules. The N-hydroxysuccinimide ester (NHS) groups at either end of the PEG5 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds.

No-Weigh products are specialty reagents provided in a pre-aliquoted format. The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. The format enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents and reducing concerns over reagent stability.

Features of BS(PEG)5:

• Reactive groups:sulfo-NHS ester (both ends)
• Reactive towards: amino groups (primary amines)
• NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds
• Water-soluble; compare to non-pegylatedBS3 (also soluble) andDSS (water-insoluble)
• Membrane-impermeable, allowing for cell surface labeling
• Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
• Polyethylene glycol spacer arms help maintain conjugate solubility
• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Ideal for small molecule or peptide conjugations

Alternative Names for BS(PEG)n:

• Bis-NHS-dPEG
• NHS-PEG-NHS
• BS(PEO)5
• Bis(NHS)PEO5
• BS-PEO9
• dPEG NHS ester
• Bis-succinimide ester PEG 400

Product References
Crosslinker Application Guide -- search for recent literature references for this product

• Reactive Moiety:Sulfo-NHS Ester

• Crosslinker Type:Homobifunctional

• Form:Powder

• Spacer:Medium(10 to 30 Å)

• Labeling Method:Chemical Labeling

• Spacer Arm Length:21.7 Å

Specifications

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• Reactivity: Amine-Amine

Names and Identifiers

• Molecular Weight: 532.5

Chemical and Physical Properties

• Solubility: Water