Allisartan isoproxil , CAS No.947331-05-7

CAS: 947331-05-7 Cat. No.: A646447 Molecular Weight: 553.01 PubChem CID: 24748496

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Allisartan isoproxil (ALS-3) is an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1 . Allisartan isoproxil is also an antihypertensive agent. Allisartan isoproxil may inhibit angiotensin-aldosterone system and oxidative stress. Allisartan isoproxil lowers blood pressure and protects the organs, preventing cerebrovascular damage. Allisartan isoproxil (80-320 mg/kg/d) has shown toxicity in rat models by targeting liver organs

In Vivo

The metabolic pathway of Allisartan isoproxil is relatively simple, and Allisartan isoproxil is completely and directly converted to EXP-3174 by esterase during gastrointestinal absorption . Allisartan isoproxil\t(20, 80 and 320 mg/kg/day; po; for 26 weeks) decreases body weight at 80-320 mg/kg/day dose, in Sprague-Dawley rats . Allisartan isoproxil\t(30 mg/kg/day; po in diet; for 55 weeks) significantly decreases stroke-related death and prolongs lifespan in stroke-prone renovascular hypertensive rats (RHR-SP). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Femal and male Sprague-Dawley rats Dosage: 20, 80 and 320 mg/kg Administration: Result: Decreased body-weight gain at 320 mg/kg/day in both sexes as well as at the 80-mg/kg/day dose in females. Decreased erythrocyte parameters in males, and decreased heart weight and exacerbation of chronic progressive nephropathy (CPN) severity in males at 80 and 320 mg/kg/day.

Form:Solid

IC50& Target:Angiotensin II Type 1

Specifications

Biochemical and Physiological Mechanisms

Allisartan isoproxil (ALS-3) is an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1 . Allisartan isoproxil is also an antihypertensive agent. Allisartan isoproxil may inhibit angiotensin-aldosterone system and oxidative stress. All

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCOC(=O)OC(C)C)Cl
• Isomeric SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCOC(=O)OC(C)C)Cl
• PubChem CID: 24748496
• Molecular Weight: 553.01

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (180.83 mM; ultrasonic and warming and heat to 60°C)
• Molecular Weight: 553.000 g/mol
• XLogP3: 6.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 14
• Exact Mass: 552.189 Da
• Monoisotopic Mass: 552.189 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 786.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1