Allo-aca - ≥99% , CAS No.A658698

CAS: A658698 Cat. No.: A658698 Summenformel: C₄₈H₇₅N₁₃O₁₅ Molekulargewicht: 1074.19

QUALITÄT & REINHEIT ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

Appearance:Solid

In Vitro:Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC 50 of 200 pM. Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression

In Vivo:In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and mg/kg/day doses, respectively. MCE has not ind

Biological Activity:Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models .

Spezifikationen

Spezifikationen & Reinheit

≥99%

Storage

Desiccated,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Reinheit

≥99%

Namen und Kennungen

Molekulargewicht

1074.19

Chemische und physikalische Eigenschaften

• Löslichkeit: H2O : 50 mg/mL (46.55 mM; Need ultrasonic)