Alpha 2 Macroglobulin from human plasma

Cat. No.: np001158

GRADE & PURITY BioReagent, ≥95%(SDS-PAGE), Extinction Coefficient: 0.81

Accession #

P01023

Übersicht

Purified Native Human Alpha 2 Macroglobulin, Human Plasma
A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Specifications

Product Name

Alpha 2 Macroglobulin from human plasma

Synonyme

A2M | alpha 2Macroglobulin | alpha 2-Macroglobulin | alpha-2-M | alpha-2-macroglobulin | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 | CPAMD5 | DKFZp779B086 | FWP007 | S863-7 | Macroglobulin Alpha-2 | A2MD

Note

BioReagent

Spezifikationen & Reinheit

BioReagent, ≥95%(SDS-PAGE), Extinction Coefficient: 0.81

Biochemische und physiologische Mechanismen

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region,

Beitritt #

P01023

Voraussichtliches Molekulargewicht

725 kDa

Molekültyp

Protein

Product Line

Biologische Produkte

Lagerung und Versand

Form

Lyophilized from 30 mM Na Phosphate, pH 7.0 , and 1 mg glycine per 1 mg Alpha 2 Macroglobulin.

Konzentration

Extinction Coefficient: 0.81

Rekonstitution

After centrifugation, we suggest addition of de-ionized H2O to the original volume, followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.

Storage

Store at -20°C,Avoid repeated freezing and thawing

Verschickt in

Ice chest + Ice pads

Stabilität und Lagerung

Store at -20℃ long term (5 years). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.

Zugehörige Ziele (menschlich)

A2M Tbio Alpha-2-macroglobulin (0 Activities)

Discover Target: A2M

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

What is the purity of this product, and how is it determined?

This product is supplied at ≥95% purity, determined by SDS-PAGE. Lot-specific values are stated on the Certificate of Analysis.

What does BioReagent mean?

BioReagent indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

How should this product be stored?

Store at ?20 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.